{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T11:04:56Z","timestamp":1792062296521,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["CRUK_A12459"],"award-info":[{"award-number":["CRUK_A12459"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005205","name":"Janssen Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005205","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MC_UU_00004\/01"],"award-info":[{"award-number":["MC_UU_00004\/01"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","award":["MRC_MC_UU_12023\/25"],"award-info":[{"award-number":["MRC_MC_UU_12023\/25"]}],"id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004339","name":"Sanofi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Abiraterone acetate plus prednisolone (AAP) previously demonstrated improved survival in STAMPEDE, a multiarm, multistage platform trial in men starting long\u2010term hormone therapy for prostate cancer. This long\u2010term analysis in metastatic patients was planned for 3\u2009years after the first results. Standard\u2010of\u2010care (SOC) was androgen deprivation therapy. The comparison randomised patients 1:1 to SOC\u2010alone with or without daily abiraterone acetate 1000\u2009mg\u2009+\u2009prednisolone 5\u00a0mg (SOC\u2009+\u2009AAP), continued until disease progression. The primary outcome measure was overall survival. Metastatic disease risk group was classified retrospectively using baseline CT and bone scans by central radiological review and pathology reports. Analyses used Cox proportional hazards and flexible parametric models, accounting for baseline stratification factors. One thousand and three patients were contemporaneously randomised (November 2011 to January 2014): median age 67\u2009years; 94% newly\u2010diagnosed; metastatic disease risk group: 48% high, 44% low, 8% unassessable; median PSA 97\u2009ng\/mL. At 6.1\u2009years median follow\u2010up, 329 SOC\u2010alone deaths (118 low\u2010risk, 178 high\u2010risk) and 244 SOC\u2009+\u2009AAP deaths (75 low\u2010risk, 145 high\u2010risk) were reported. Adjusted HR\u00a0=\u00a00.60 (95% CI: 0.50\u20100.71;\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0=\u00a00.31\u2009\u00d7\u200910\n                    <jats:sup>\u22129<\/jats:sup>\n                    ) favoured SOC\u2009+\u2009AAP, with 5\u2010years survival improved from 41% SOC\u2010alone to 60% SOC\u2009+\u2009AAP. This was similar in low\u2010risk (HR\u00a0=\u00a00.55; 95% CI: 0.41\u20100.76) and high\u2010risk (HR\u00a0=\u00a00.54; 95% CI: 0.43\u20100.69) patients. Median and current maximum time on SOC\u2009+\u2009AAP was 2.4 and 8.1\u2009years. Toxicity at 4\u2009years postrandomisation was similar, with 16% patients in each group reporting grade 3 or higher toxicity. A sustained and substantial improvement in overall survival of all metastatic prostate cancer patients was achieved with SOC\u2009+\u2009abiraterone acetate + prednisolone, irrespective of metastatic disease risk group.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34018","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T08:14:22Z","timestamp":1649751262000},"page":"422-434","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5\u2010year follow\u2010up results from the STAMPEDE randomised trial (NCT00268476)"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7314-8204","authenticated-orcid":false,"given":"Nicholas D.","family":"James","sequence":"first","affiliation":[{"name":"Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7776-8059","authenticated-orcid":false,"given":"Noel W.","family":"Clarke","sequence":"additional","affiliation":[{"name":"The Departments of Surgery &amp; Urology The Christie &amp; Salford Royal Hospitals  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-2632","authenticated-orcid":false,"given":"Adrian","family":"Cook","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit at UCL, Institute of Clinical Trials &amp; Methodology, UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8344-3776","authenticated-orcid":false,"given":"Adnan","family":"Ali","sequence":"additional","affiliation":[{"name":"The Christie NHS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex P.","family":"Hoyle","sequence":"additional","affiliation":[{"name":"Salford Royal HS Foundation Trust  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4811-7983","authenticated-orcid":false,"given":"Gerhardt","family":"Attard","sequence":"additional","affiliation":[{"name":"UCL Cancer Institute, University College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3641-278X","authenticated-orcid":false,"given":"Christopher D.","family":"Brawley","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit at UCL, Institute of Clinical Trials &amp; Methodology, UCL  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Guy's, King's, &amp; St. Thomas' Hospitals, and Sarah Cannon Research Institute  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9276-3053","authenticated-orcid":false,"given":"William R.","family":"Cross","sequence":"additional","affiliation":[{"name":"St James University Hospital  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3954-2806","authenticated-orcid":false,"given":"David P.","family":"Dearnaley","sequence":"additional","affiliation":[{"name":"The Institute of Cancer Research and Royal Marsden NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2034-595X","authenticated-orcid":false,"given":"Johann S.","family":"de Bono","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9082-4596","authenticated-orcid":false,"given":"Carlos","family":"Diaz\u2010Montana","sequence":"additional","affiliation":[{"name":"MRC Clinical Trials Unit at UCL, Institute of Clinical Trials &amp; 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Abiraterone acetate and prednisolone with or without enzalutamide for high\u2010risk non\u2010metastatic prostate cancer: a meta\u2010analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol","volume":"399","author":"Attard G","year":"2022","journal-title":"Lancet"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.34018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T19:11:21Z","timestamp":1692817881000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,16]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["10.1002\/ijc.34018"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34018","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,16]]},"assertion":[{"value":"2021-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}