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We assessed triage performance and predictive value of human gene methylation panel (ZNF671\/ASTN1\/ITGA4\/RXFP3\/SOX17\/DLX1) alone and with combination of HPV16\/18 genotyping in a longitudinal screening study. Out of 9526 women at baseline, 1758 women positive for hrHPV on self\u2010collected samples followed up yearly were included in the current analysis. Satisfactory risk stratification to detect cervical intraepithelial neoplasia grade 2 or worse (CIN2+) was demonstrated by the methylation panel with an odds ratio (OR) of 11.3 among methylation\u2010positive women compared to methylation\u2010negative counterparts. Triaging with methylation panel reduced colposcopy referral rate by 67.2% with sensitivity and specificity of 83.0% and 69.9% to detect CIN2+. The corresponding values for the combining methylation and HPV 16\/18 were 96.6% and 58.3%. The cumulative 3\u2010year incident CIN2+ risk was 6.8% (95% CI: 4.9%\u20108.6%) for hrHPV positive women, which was reduced to 4.5% (95% CI: 2.7%\u20106.3%) and 2.9% (95% CI: 1.2%\u20104.5%) for women negative on methylation triaging alone and negative on the combined strategy. The corresponding risk for women positive for both methylation and HPV 16\/18 reached 33.7% (95% CI: 19.0%\u201045.8%). Our study demonstrated the satisfactory triage performance and predictive value of the methylation panel, especially in combination with HPV 16\/18 genotyping. The substantially lower risk of CIN2+ among the triage negative women over the next 3\u2009years suggests that the interval for repeat HPV test can be safely extended to at least 2\u2009years.<\/jats:p>","DOI":"10.1002\/ijc.34041","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T04:33:11Z","timestamp":1650688391000},"page":"878-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Triage performance and predictive value of the human gene methylation panel among women positive on self\u2010collected <scp>HPV<\/scp> test: Results from a prospective cohort study"],"prefix":"10.1002","volume":"151","author":[{"given":"Li","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"},{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangying","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Dong","sequence":"additional","affiliation":[{"name":"Institutes of Biomedical Sciences Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 L.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Muwonge","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-0005","authenticated-orcid":false,"given":"Fanghui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0124-4050","authenticated-orcid":false,"given":"Partha","family":"Basu","sequence":"additional","affiliation":[{"name":"International Agency for Research on Cancer  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","unstructured":"World Health Organization (WHO).WHO director\u2010general calls for all countries to take action to help end the suffering caused by cervical cancer. 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