{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T03:18:17Z","timestamp":1789442297652,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adjuvant chemotherapy has become standard of care for pancreatic ductal adenocarcinoma (PDAC) as it improves patient outcome. However, its clinical meaning in early\u2010stage, UICC I tumors remains uncertain. We examined the effect of adjuvant therapy on disease\u2010free survival (DFS) and overall survival (OS) of UICC stage I PDAC patients treated at an academic tertiary care center between 2000 and 2016. Among 124 patients (69 male, 55 female; median age 68\u2009years, range 41\u201084\u2009years) with UICC stage I disease, adjuvant therapy improved both DFS (19.8 vs 12.8\u00a0months, HR 0.59, 95% CI: 0.37\u20100.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.03) and OS (40.9 vs 20.3\u00a0months, HR 0.54, 95% CI: 0.35\u20100.84, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). Multivariate analyses and propensity score matching confirmed the prognostic impact of adjuvant therapy independent of localization, differentiation and R\u2010status. Thus, every patient with UICC I PDAC should receive adjuvant chemotherapy as it may improve outcome significantly. Our findings support the concept of PDAC as systemic disease from early stages on.<\/jats:p>","DOI":"10.1002\/ijc.34044","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T14:30:06Z","timestamp":1650897006000},"page":"914-919","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The impact of adjuvant therapy on outcome in <scp>UICC<\/scp> stage I pancreatic cancer"],"prefix":"10.1002","volume":"151","author":[{"given":"Michael","family":"Guenther","sequence":"first","affiliation":[{"name":"Institute of Pathology, Faculty of Medicine Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Boeck","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III Grosshadern University Hospital, Ludwig\u2010Maximilians\u2010University  Munich Germany"},{"name":"German Cancer Consortium 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