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However, most studies have limited their analyses to any breastfeeding, and only a few data have examined exclusive breastfeeding, or other exposures such as formula milk. We performed pooled analyses and individual participant data metaanalyses of data from 16 studies (N\u00a0=\u00a017\u2009189 controls; N\u00a0=\u00a010\u2009782 ALL and N\u00a0=\u00a01690 AML cases) from the Childhood Leukemia International Consortium (CLIC) to characterize the associations of breastfeeding duration with ALL and AML, as well as exclusive breastfeeding duration and age at introduction to formula with ALL. In unconditional multivariable logistic regression analyses of pooled data, we observed decreased odds of ALL among children breastfed 4 to 6\u00a0months (0.88, 95% CI 0.81\u20100.96) or 7 to 12\u2009months (OR 0.85, 0.79\u20100.92). We observed a similar inverse association between breastfeeding \u22654\u00a0months and AML (0.82, 95% CI 0.71\u20100.95). Odds of ALL were reduced among children exclusively breastfed 4 to 6\u00a0months (OR 0.73, 95% CI 0.63\u20100.85) or 7 to 12\u2009months (OR 0.70, 95% CI 0.53\u20100.92). Random effects metaanalyses produced similar estimates, and findings were unchanged in sensitivity analyses adjusted for race\/ethnicity or mode of delivery, restricted to children diagnosed \u22651\u00a0year of age or diagnosed with B\u2010ALL. Our pooled analyses indicate that longer breastfeeding is associated with decreased odds of ALL and AML. Few risk factors for ALL and AML have been described, therefore our findings highlight the need to promote breastfeeding for leukemia prevention.<\/jats:p>","DOI":"10.1002\/ijc.34062","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T08:49:56Z","timestamp":1652086196000},"page":"1013-1023","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer &amp; Leukemia International Consortium"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6674-9562","authenticated-orcid":false,"given":"Jeremy M.","family":"Schraw","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"},{"name":"Texas Children's Cancer and Hematology Centers, Texas Children's Hospital  Houston Texas 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