{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:08:59Z","timestamp":1777496939670,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T00:00:00Z","timestamp":1655424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874036"],"award-info":[{"award-number":["81874036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["19411971100"],"award-info":[{"award-number":["19411971100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Global phase 3 trials have demonstrated the priority of several next\u2010generation anaplastic lymphoma kinase\u2010tyrosine kinase inhibitors (ALK\u2010TKIs). However, clinical studies are conducted with specific populations that differ from the real world. The study aimed to evaluate the clinical outcomes of alectinib in real\u2010world settings. Patients with advanced nonsmall\u2010cell lung cancer (NSCLC) and <jats:italic>EML4\u2010ALK<\/jats:italic> fusion were enrolled from two medical centers between June 2018 and June 2020. The primary endpoints were objective response rate (ORR) and progression\u2010free survival (PFS) to alectinib. The secondary endpoint was response of brain metastases. The risk factors for disease progression were also investigated. In total, 127 patients with advanced NSCLC were enrolled into this study. Of them, 54.3% received first\u2010line alectinib. The 1\u2010 and 2\u2010year PFS rates were 77.4% and 68.3%, respectively. ORR and disease control rate (DCR) were 53.5% and 91.3%, respectively. Among patients with brain metastases, intracranial ORR and DCR were 63.6% and 88.6%, respectively. In addition, we found that \u201ccrizotinib pretreatment\u201d, \u201cliver metastasis\u201d and \u201c<jats:italic>TP53<\/jats:italic> co\u2010mutation\u201d were individually associated with shorter PFS in alectinib treatment. In conclusion, this study confirms the salient clinical outcomes of alectinib for <jats:italic>ALK<\/jats:italic>\u2010fusion\u2010driven NSCLC patients with or without brain metastases, adding real\u2010world evidence to the priority of alectinib in clinical practice.<\/jats:p>","DOI":"10.1002\/ijc.34123","type":"journal-article","created":{"date-parts":[[2022,5,17]],"date-time":"2022-05-17T16:45:35Z","timestamp":1652805935000},"page":"15-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Special issue \u201cThe advance of solid tumor research in China\u201d: Real\u2010world clinical outcomes of alectinib for advanced nonsmall\u2010cell lung cancer patients with <scp>ALK<\/scp> fusion in China"],"prefix":"10.1002","volume":"152","author":[{"given":"Chunxia","family":"Su","sequence":"first","affiliation":[{"name":"Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2500-6110","authenticated-orcid":false,"given":"Juan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiping","family":"Qiang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6199-1157","authenticated-orcid":false,"given":"Qing","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianxiu","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengqing","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shanghai Pulmonary Hospital and Thoracic Cancer Institute Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianqing","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Shanghai Chest Hospital Shanghai Jiao Tong University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.8122112"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw301"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05945"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.6993"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-1123"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1408440"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.9518"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704795"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00505"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027187"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30123-X"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsb1609216"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cas.13977"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1556-0864(21)01996-1"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-16-0596"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2021.01.1214"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.12.009"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70362-6"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.65.8732"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.2294"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-19-346"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.03.007"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.21037\/tlcr-21-160"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy333"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-2853"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34123","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.34123","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34123","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:07:39Z","timestamp":1692630459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,17]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/ijc.34123"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34123","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,17]]},"assertion":[{"value":"2021-11-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}