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Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS\u2010LSIL Triage Study (ALTS) and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high\u2010grade cervical abnormalities at any point during follow\u2010up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged &lt;30\u2009years). We used survival approaches accounting for interval\u2010censoring to estimate the time to clearance distribution for 20\u2009529 HPV infections (64% were incident and 51% were carcinogenic). 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