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We aimed to examine the racial\/ethnic disparities in NPC incidence, treatment, and mortality with a specific focus on AA subgroups. NPC patients aged \u226515\u2009years were obtained from the Surveillance, Epidemiology, and End Results (SEER) 18 (1975\u20102018). AAs were divided into Chinese, Filipino, Vietnamese, Hawaiian, Japanese, Laotian, Korean, Cambodian, Indian\/Pakistani and other Asian\/Pacific Islanders (APIs). Age\u2010adjusted incidence was calculated using the SEER*Stat software. Cox proportional and Fine\u2010Gray subdistribution hazard models were used to calculate overall and cause\u2010specific mortalities after adjusting for confounders. Among the total 11\u2009964 NPC cases, 18.4% were Chinese, 7.7% Filipino, 5.0% Vietnamese, 1.2% Hawaiian, 1.0% Japanese, 0.8% Laotian, 0.8% Korean, 0.6% Cambodian, 0.5% Indian\/Pakistani and 4.4% other APIs. Laotians had the highest age\u2010adjusted NPC incidence (9.21 per 100\u2009000), which was 18.04 times higher than it in non\u2010Hispanic Whites (NHWs). Chinese and Filipinos observed lower overall mortalities, however, Chinese saw increased NPC\u2010specific mortality than NHWs. Disparities in mortality were also found across different histology subtypes. This is the first and largest study examining the NPC incidence and outcomes in AA subgroups. The significant disparities of NPC within AAs underline the importance of adequate AA\u2010subgroup sample size in future studies to understand the prognostic role of ethnicity in NPC and advocate more ethnically and culturally tailored cancer prevention and care delivery.<\/jats:p>","DOI":"10.1002\/ijc.34154","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T15:24:43Z","timestamp":1654529083000},"page":"1291-1303","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Racial and ethnic disparities in nasopharyngeal cancer with an emphasis among Asian Americans"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1201-865X","authenticated-orcid":false,"given":"Qian","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2788-4064","authenticated-orcid":false,"given":"Hui","family":"Xie","sequence":"additional","affiliation":[{"name":"Joseph J Zilber School of Public Health University of Wisconsin\u2010Milwaukee  Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannan","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology, Department of Medicine Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"Department of Medicine Icahn School of Medicine at Mount Sinai Morningside and West  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Surgery Cleveland Clinic Foundation  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changchuan","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Medicine Roswell Park Comprehensive Cancer Center  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine and Public Health Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura S.","family":"Rozek","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences and Otolaryngology University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Boffetta","sequence":"additional","affiliation":[{"name":"Department of Family, Population &amp; Preventive Medicine Stony Brook University  Stony Brook New York USA"},{"name":"Department of Medical and Surgical Sciences University of Bologna  Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,22]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"International Agency for Research on Cancer World Health Organization.GLOBOCAN.http:\/\/globocan.iarc.fr. 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