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We used the health care utilisation databases of the Lombardy region to identify cancer patients' characteristics (eg, sex, age) and cancer\u2010related information (eg, cancer site, stage at diagnosis). The frequency of new cancer diagnoses in 2019 and 2020 were compared in terms of percentage differences in undiagnosed cases. We observed two peaks in the decline in cancer diagnoses: March to May 2020 (\u221237%) and October to December 2020 (\u221219%). The decline persisted over the course of 2020 and was higher in males and patients aged 74+. Diagnoses of all four common cancers analysed (female breast, lung, colorectal and prostate) remained below pre\u2010pandemic levels. For breast and colorectal cancers, the decline in diagnoses was high in the age groups targeted by population\u2010based screening programmes. We observed a reduction in localised stage cancer diagnoses for all four cancers. 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