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In order to evaluate the impact and feasibility of opt\u2010in self\u2010sampling in the Finnish setting, we invited a randomized population of 5350 women not attending screening after age group invitation or after reminder, to attend HPV self\u2010sampling\u2010based screening in the autumn of 2018 in Helsinki. Out of those, 1282 (24.0%) expressed their interest and ordered the sampling package. Eventually 787 women (14.7% of the total invited population) took part in screening, 770 women by providing a vaginal sample within 2\u00a0months from invitation and 17 by providing a pap smear in the laboratory. Self\u2010taken samples were collected in Aptima Multitest vials and tested using the Aptima HPV mRNA assay. A high proportion, 158\/770 (20.5%) of the samples were positive in the Aptima HPV assay. One hundred and forty\u2010one samples were further submitted to Aptima HPV Genotyping and extended genotyping by a Luminex based assay. Of those, 23 samples (16.3%) were HPV 16 positive and 7 (5.0%) were positive for HPV 18\/45; extended genotyping revealed multiple high\u2010risk and low\u2010risk HPV genotypes. At follow\u2010up seven cases of high\u2010grade squamous intraepithelial lesion (HSIL) were diagnosed, which represents 4.4% of HPV positive women and 0.9% of screened women, whereas the rate was 0.5% in routine screening. Our findings suggest that self\u2010sampling with HPV mRNA testing is a feasible approach to improve screening efficacy in a high\u2010risk population among original nonattendees.<\/jats:p>","DOI":"10.1002\/ijc.34170","type":"journal-article","created":{"date-parts":[[2022,6,18]],"date-time":"2022-06-18T13:48:21Z","timestamp":1655560101000},"page":"1989-1996","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Human papillomavirus self\u2010sampling with <scp>mRNA<\/scp> testing benefits routine screening"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2094-985X","authenticated-orcid":false,"given":"Eeva","family":"Auvinen","sequence":"first","affiliation":[{"name":"Department of Virology Helsinki University Hospital Diagnostic Center and University of Helsinki and HUS  Helsinki 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