{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:24:41Z","timestamp":1771669481366,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T00:00:00Z","timestamp":1657929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772483"],"award-info":[{"award-number":["81772483"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Conventional imaging examinations are not sensitive enough for the early detection of recurrent or metastatic lesions in renal cell carcinoma (RCC) patients. We aimed to explore the role of <jats:sup>68<\/jats:sup>Ga\u2010prostate specific membrane antigen (PSMA)\u201011 positron emission tomography (PET)\/computed tomography (CT) in the detection of primary and metastatic lesions in such patients. We retrospectively analyzed 50 RCC patients who underwent <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT from November 2017 to December 2020. We observed a higher median accuracy and tumor\u2010to\u2010background maximum standard uptake value (SUV<jats:sub>max<\/jats:sub>) ratio (TBR) of <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT in clear cell RCC (ccRCC; 96.57% and 6.00, respectively) than in non\u2010clear cell RCC (ncRCC; 82.05% and 2.99, respectively). The accuracies in detecting lesions in the renal region, bone, lymph nodes and lungs in ccRCC were 100.00%, 95.00%, 98.08% and 75.00%, respectively, and those in the renal region, bone and lymph nodes in ncRCC were 100.00%, 86.67% and 36.36%, respectively. The median TBRs of the lesions from the above locations were 0.38, 10.96, 6.69 and 13.71, respectively, in ccRCC and 0.13, 4.02 and 0.73, respectively, in ncRCC. The PSMA score evaluated with immunohistochemistry was correlated with the SUV<jats:sub>max<\/jats:sub> (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.046) in RCC. Higher PSMA scores were observed in ccRCC than in ncRCC (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.031). <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT resulted in changes in clinical management in 12.9% (4\/31) of cases because of the discovery of new metastases not detected with conventional imaging. These results indicate that <jats:sup>68<\/jats:sup>Ga\u2010PSMA\u201011 PET\/CT is a promising method for the detection of metastatic lesions in ccRCC, especially for those in the bone and lymph nodes.<\/jats:p>","DOI":"10.1002\/ijc.34189","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T07:00:11Z","timestamp":1656140411000},"page":"42-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Special issue \u201cThe advance of solid tumor research in China\u201d: 68Ga\u2010PSMA\u201011 PET\/CT for evaluating primary and metastatic lesions in different histological subtypes of renal cell carcinoma"],"prefix":"10.1002","volume":"152","author":[{"given":"Yilin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Sun Yat\u2010sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer 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