{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:13:00Z","timestamp":1747149180389,"version":"3.40.5"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2020\u201005866"],"award-info":[{"award-number":["2020\u201005866"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Androgen deprivation therapy (ADT) has been hypothesized to protect against COVID\u201019, but previous observational studies of men with prostate cancer on ADT have been inconsistent regarding mortality risk from coronavirus disease 2019 (COVID\u201019). Using data from the Prostate Cancer data Base Sweden (PCBaSe), we identified a cohort of 114\u2009547 men with prevalent prostate cancer on the start of follow\u2010up in February 2020, and followed them until 16 December 2020 to evaluate the association between ADT and time to test positive for COVID\u201019. Among men testing positive for COVID\u201019, we used regression analyses to estimate the association between ADT and risk of COVID\u201019\u2010related hospital admission\/death from any cause within 30\u2009days of the positive test. In total, 1695 men with prostate cancer tested positive for COVID\u201019. In crude analyses, exposure to ADT was associated with a 3\u2010fold increased risk of both testing positive for COVID\u201019 infection and subsequent hospital admission\/death. Adjustment for age, comorbidity and prostate cancer risk category substantially attenuated the associations: HR 1.3 (95% CI: 1.1\u20101.5) for testing positive for COVID\u201019, and OR 1.4 (95% CI: 1.0\u20101.9) for risk of subsequent hospital admission\/death. In conclusion, although these results suggest increased risks of a positive COVID\u201019 test, and COVID\u201019\u2010related hospital admission\/death in men on ADT, these findings are likely explained by confounding by old age, cancer\u2010associated morbidity and other comorbidities being more prevalent in men on ADT, rather than a direct effect of the therapy.<\/jats:p>","DOI":"10.1002\/ijc.34204","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T16:19:46Z","timestamp":1657297186000},"page":"1925-1934","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Susceptibility to <scp>SARS\u2010Cov<\/scp>\u20102 infection and risk for severe <scp>COVID<\/scp>\u201019 in patients with prostate cancer on androgen deprivation therapy"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8850-7863","authenticated-orcid":false,"given":"Rolf","family":"Gedeborg","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacy","family":"Loeb","sequence":"additional","affiliation":[{"name":"Department of Urology and Population Health New York University and Manhattan Veterans Affairs Medical Center  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Styrke","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Urology and Andrology Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritva","family":"Kiiski\u2010Berggren","sequence":"additional","affiliation":[{"name":"Department of Surgical and Perioperative Sciences, Anesthesiology and Intensive Care Medicine Ume\u00e5 University  Ume\u00e5 Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Garmo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"},{"name":"Translational Oncology and Urology Research (TOUR), King's College London Guy's Hospital  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e4r","family":"Stattin","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University  Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe7199"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2020.05.007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.04.479"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-0348-8"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2021.2019304"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyv305"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802247664"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-017-0316-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12613"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-11-450"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365590903024577"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.2807\/esm.11.05.00626-en"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03511-x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2019.1702093"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-012-1290-x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0393-2249.19.03595-1"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/21681805.2020.1750475"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092550"},{"volume-title":"Nationellt v\u00e5rdprogram f\u00f6r prostatacancer; version 6.1. 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