{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:46:59Z","timestamp":1773330419026,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","award":["DS 174"],"award-info":[{"award-number":["DS 174"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010621","name":"Uniwersytet Medyczny w Lublinie","doi-asserted-by":"publisher","award":["PBsd 251"],"award-info":[{"award-number":["PBsd 251"]}],"id":[{"id":"10.13039\/501100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,2,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Multiple myeloma (MM) and chronic lymphocytic leukemia (CLL) patients have increased morbidity and mortality rates of COVID\u201019 due to immunosuppression associated with the disease and ongoing therapy. The same immune impairment accompanying CLL and MM also affects suboptimal vaccine response. The study assessed the effectiveness of the humoral and T cell\u2010mediated immunity following mRNA COVID\u201019 vaccination (using either BNT162b2 or mRNA\u20101273) in short\u2010term (2\u20105\u2009weeks after second dose) and long\u2010term follow\u2010up (12\u2009weeks after vaccination). Between March and August 2021, blood samples were obtained from 62 CLL and 60\u2009MM patients from eight different hematology departments in Poland. Total anti\u2010RBD antibodies were detected in 37% MM patients before vaccination, increased to 91% and 94% in short\u2010 and long\u2010term follow\u2010up, respectively. In CLL, serological responses were detectable in 21% of patients before vaccination and increased to 45% in the short\u2010term and 71% in long\u2010term observation. We detected a tendency to higher frequencies of specific CD8+ T cells against SARS\u2010CoV\u20102 after vaccination compared to samples before vaccination in MM patients and no changes in frequencies of specific T cells in CLL patients. Our study provides novel insights into mRNA vaccination efficacy in immunocompromised MM and CLL patients, and our findings highlight that specific CD8+ T cells against SARS\u2010CoV\u20102 might be induced by vaccination but do not correlate positively with serological responses.<\/jats:p>","DOI":"10.1002\/ijc.34209","type":"journal-article","created":{"date-parts":[[2022,7,13]],"date-time":"2022-07-13T15:51:40Z","timestamp":1657727500000},"page":"705-712","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Response to <scp>anti\u2010SARS\u2010CoV<\/scp>\u20102 <scp>mRNA<\/scp> vaccines in multiple myeloma and chronic lymphocytic leukemia patients"],"prefix":"10.1002","volume":"152","author":[{"given":"Joanna","family":"Zaleska","sequence":"first","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Kwasnik","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Paziewska","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Purkot","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Szabelak","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Jurek","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Masny","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Dziatkiewicz","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Pronobis\u2010Szczylik","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Piebiak","sequence":"additional","affiliation":[{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Szymczyk","sequence":"additional","affiliation":[{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"},{"name":"Department of Clinical Transplantology Medical University of Lublin  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Jarosz\u2010Chudzik","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Bolkun","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Bialystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Kozlowska","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Bialystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Piszcz","sequence":"additional","affiliation":[{"name":"Department of Hematology Medical University of Bialystok  Bia\u0142ystok Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edyta","family":"Subocz","sequence":"additional","affiliation":[{"name":"Department of Hematology Warmian\u2010Masurian Cancer Center of the Ministry of the Interior and Administration's Hospital  Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Halka","sequence":"additional","affiliation":[{"name":"Department of Hematology Warmian\u2010Masurian Cancer Center of the Ministry of the Interior and Administration's Hospital  Olsztyn Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Bator","sequence":"additional","affiliation":[{"name":"Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elzbieta","family":"Kalicinska","sequence":"additional","affiliation":[{"name":"Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Wrobel","sequence":"additional","affiliation":[{"name":"Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lidia","family":"Usnarska\u2010Zubkiewicz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justyna","family":"Rybka","sequence":"additional","affiliation":[{"name":"Department of Hematology, Blood Neoplasms and Bone Marrow Transplantation Wroclaw Medical University  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabela","family":"Deren\u2010Wagemann","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantation Lower Silesian Center of Oncology  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Szyca\u2010Smieszniak","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantation Lower Silesian Center of Oncology  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaroslaw","family":"Dybko","sequence":"additional","affiliation":[{"name":"Department of Hematology and Transplantation Lower Silesian Center of Oncology  Wroc\u0142aw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwona","family":"Hus","sequence":"additional","affiliation":[{"name":"Department of Clinical Transplantology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Pula","sequence":"additional","affiliation":[{"name":"Department of Hematology Institute of Hematology and Transfusion Medicine  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edyta","family":"Cichocka","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Nicolaus Copernicus Hospital  Torun Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcin","family":"Rymko","sequence":"additional","affiliation":[{"name":"Department of Hematology and Bone Marrow Transplantation Nicolaus Copernicus Hospital  Torun Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorota","family":"Zdunczyk","sequence":"additional","affiliation":[{"name":"Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mateusz","family":"Ziarkiewicz","sequence":"additional","affiliation":[{"name":"Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grzegorz Wladyslaw","family":"Basak","sequence":"additional","affiliation":[{"name":"Department of Hematology, Transplantation and Internal Medicine Medical University of Warsaw  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Bullinger","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology, and Tumor Immunology Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, Corporate Member of Freie Universit\u00e4t Berlin and Humboldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"},{"name":"German Cancer Consortium (Deutsches Konsortium f\u00fcr Translationale Krebsforschung; DKTK)  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0135-4030","authenticated-orcid":false,"given":"Krzysztof","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"Department of Experimental Hematooncology Medical University of Lublin  Lublin Poland"},{"name":"Department of Hematology St John's Cancer Centre  Lublin Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"https:\/\/covid19.who.int\/;2021. Accessed December 5 2021."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011568"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020008150"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020006965"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-020-0959-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00278-7"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-03-567388"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2135-z"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279196"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.671633"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25698"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01386-7"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01380-5"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00534-z"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-152515"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17608"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2021.06.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-21-0139"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01354-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-021-00528-x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2899"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020325"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253638"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-1221"},{"key":"e_1_2_11_26_1","first-page":"1","article-title":"T\u2010cell immune response after mRNA SARS\u2010CoV\u20102 vaccines is frequently detected also in the absence of seroconversion in patients with lymphoid malignancies","volume":"196","author":"Marasco V","year":"2021","journal-title":"Br J Haematol"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abl5344"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.34209","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T12:36:52Z","timestamp":1692448612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,27]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,2,15]]}},"alternative-id":["10.1002\/ijc.34209"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34209","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,27]]},"assertion":[{"value":"2022-01-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}