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In the present study, we performed a bidirectional summary\u2010level Mendelian randomization (MR) analysis to elucidate the causal relationships of C\u2010reactive protein (CRP) and inflammatory regulators with MM. Summary\u2010level data of genetic variants associated with inflammation were extracted from two genome\u2010wide association studies (GWASs) on CRP and human cytokines, while data on\u00a0MM was from large meta\u2010analyses of GWASs among 372\u2009617 UK Biobank participants. The inverse\u2010variance weighted (IVW) method was used as the primary MR analysis and MR\u2010Egger, weighted median, and MR\u2010pleiotropy residual sum and outlier (MR\u2010PRESSO) were used as the sensitivity analyses. Our results suggested\u00a0that higher levels of monocyte\u2010specific chemokine\u20103 (IVW estimate odds ratio [OR<jats:sub>IVW<\/jats:sub>] per SD genetic cytokines change: 1.24; 95% confidence interval [CI]: 1.03\u20101.49; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), vascular endothelial growth factor (1.14, 1.03\u20101.27; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02), interleukin\u201010 (1.33, 1.01\u20101.75; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04) and interleukin\u20107 (1.24, 1.03\u20101.48; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.02) were associated with increased risk of MM, while lower levels of tumor necrosis factor\u2010\u03b2 (0.84, 0.74\u20100.92; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001) was strongly associated with an increased risk of MM. And conversely, genetically predicted MM was related to increased levels of interleukin\u201017 (IVW estimate <jats:italic>\u03b2<\/jats:italic>: 0.051, 95% CI: 0.018\u20100.085; <jats:italic>P<\/jats:italic>\u00a0=\u00a02.7\u2009\u00d7\u200910<jats:sup>\u22123<\/jats:sup>). Besides, we observed no such significant associations for other inflammatory factors in our study. Overall, our study provides genetic evidence on the relationships of CRP and systemic inflammatory regulators with MM. Targeted interventions of specific inflammatory factors may have implications to alleviate MM cancer risk.<\/jats:p>","DOI":"10.1002\/ijc.34214","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T15:03:29Z","timestamp":1657983809000},"page":"1750-1759","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Causal relationships between inflammatory factors and multiple myeloma: A bidirectional Mendelian randomization study"],"prefix":"10.1002","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0421-7314","authenticated-orcid":false,"given":"Qiangsheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology Ningbo Hangzhou Bay Hospital  Ningbo Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiqin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ningbo Hangzhou Bay 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