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We examined dietary fat in relation to all\u2010cause mortality and cancer progression or death among 1149 people in the Cancer and Leukemia Group B (Alliance)\/Southwest Oncology Group (SWOG) 80405 trial who completed a food frequency questionnaire at initiation of treatment for advanced or metastatic colorectal cancer. We examined saturated, monounsaturated, total and specific types (n\u20103, long\u2010chain n\u20103 and n\u20106) of polyunsaturated fat, animal\u00a0and vegetable fats. We hypothesized higher vegetable fat intake would be associated with lower risk of all\u2010cause mortality and cancer progression. We used Cox proportional hazards regression to estimate adjusted hazard ratios (HR) and 95% confidence intervals (CI). Over median follow\u2010up of 6.1\u2009years (interquartile range [IQR]: 5.3, 7.2 y), we observed 974 deaths and 1077 events of progression or death. Participants had a median age of 59 y; 41% were female and 86% identified as White. Moderate or higher vegetable fat was associated with lower risk of mortality and cancer progression or death (HRs comparing second, third and fourth to first quartile for all\u2010cause mortality: 0.74 [0.62, 0.90]; 0.75 [0.61, 0.91]; 0.79 [0.63, 1.00];<jats:italic>P<\/jats:italic>trend: .12; for cancer progression or death: 0.74 [0.62, 0.89]; 0.78 [0.64, 0.95]; 0.71 [0.57, 0.88];<jats:italic>P<\/jats:italic>trend: .01). No other fat type was associated with all\u2010cause mortality and cancer progression or death. Moderate or higher vegetable fat intake may be associated with lower risk of cancer progression or death among people with metastatic colorectal cancer.<\/jats:p>","DOI":"10.1002\/ijc.34230","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:49:38Z","timestamp":1659109778000},"page":"123-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Dietary fat in relation to all\u2010cause mortality and cancer progression and death among people with metastatic colorectal cancer: Data from<scp>CALGB<\/scp>80405 (Alliance)\/<scp>SWOG<\/scp>80405"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-3385","authenticated-orcid":false,"given":"Erin L.","family":"Van Blarigan","sequence":"first","affiliation":[{"name":"University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ma","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Shu","family":"Ou","sequence":"additional","affiliation":[{"name":"Alliance Statistics and Data Management Center Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany M.","family":"Bainter","sequence":"additional","affiliation":[{"name":"Alliance Statistics and Data Management Center Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan P.","family":"Venook","sequence":"additional","affiliation":[{"name":"University of California, San Francisco San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmie","family":"Ng","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Niedzwiecki","sequence":"additional","affiliation":[{"name":"Duke Cancer Institute Duke University Durham North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Giovannucci","sequence":"additional","affiliation":[{"name":"Harvard T.H. 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