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To further evaluate vaccine impact including cross\u2010protection and type replacement, we described high\u2010risk (HR)\u2010HPV type\u2010specific cervical precancer incidence rates among women aged 20 to 39\u2009years, 2008 to 2016. We analyzed cross\u2010sectional population\u2010based data on 18\u2009344 cases of CIN2+ from a 5\u2010site surveillance system. Diagnostic specimens were tested for individual HPV types, including 14 HR\u2010HPV types (HPV16\/18\/31\/33\/35\/39\/45\/51\/52\/56\/58\/59\/66\/68). We estimated age\u2010specific annual HR\u2010HPV type\u2010specific CIN2+ incidence per 100\u2009000 screened women for individual types, vaccine HR\u2010HPV types (HPV16\/18) and nonvaccine HR\u2010HPV types (non\u2010HPV16\/18). We evaluated trends using average annual percent changes (AAPC) and 95% confidence intervals (CI), and estimated total declines by comparing 2015\u20102016 to 2008\u20102009 using incidence rate ratios. Among 20\u201024\u2010year\u2010olds, HPV16\/18\u2010CIN2+ declined from 2008 through 2016 (AAPC: \u221221.3%, 95% CI: \u221228.1%, \u221213.8%), whereas no trend was observed for non\u2010HPV16\/18\u2010CIN2+ (AAPC: \u22121.8%, 95% CI: \u22128.1%, 4.9%). After 2010, CIN2+ among 20\u201024\u2010year\u2010olds was more often caused by nonvaccine vs vaccine HR\u2010HPV types. No significant declining trends were observed in older age groups. In 2015\u20102016 compared with 2008\u20102009, HPV16\u2010CIN2+ declined 78%, HPV18\u2010CIN2+ 72% and HPV31\u2010CIN2+ 51% among 20\u201024\u2010year\u2010olds; no increases were observed in type\u2010specific CIN2+ incidence. Among 25\u201029\u2010year\u2010olds, HPV16\u2010CIN2+ declined 18%; CIN2+ attributed to seven nonvaccine types increased significantly. No significant declines were observed in older groups. Significant declines in HPV16\/18\u2010CIN2+ in 20\u201024\u2010year\u2010olds and HPV16\u2010CIN2+ in 25\u201029\u2010year\u2010olds corroborate impact of HPV vaccination. A declining trend in HPV31\u2010CIN2+ is consistent with cross\u2010protection from vaccination.<\/jats:p>","DOI":"10.1002\/ijc.34231","type":"journal-article","created":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:49:45Z","timestamp":1659109785000},"page":"137-150","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["HPV type\u2010specific trends in cervical precancers in the United States, 2008 to 2016"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9976-178X","authenticated-orcid":false,"given":"Julia W.","family":"Gargano","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"McClung","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rayleen M.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention  Atlanta Georgia USA"},{"name":"Synergy America, Inc.  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M.","family":"Niccolai","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program at Yale  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Brackney","sequence":"additional","affiliation":[{"name":"Connecticut Emerging Infections Program at Yale  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"DeBess","sequence":"additional","affiliation":[{"name":"Oregon Department of Human Services  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ehlers","sequence":"additional","affiliation":[{"name":"Oregon Department of Human Services  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy M.","family":"Bennett","sequence":"additional","affiliation":[{"name":"University of Rochester School of Medicine and Dentistry  Rochester New York 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