{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:58:17Z","timestamp":1777499897998,"version":"3.51.4"},"reference-count":52,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["Intramural Research Program"],"award-info":[{"award-number":["Intramural Research Program"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pancreatic cancer (PC) is highly fatal, and its incidence is increasing in the United States. Population\u2010based registry studies suggest associations between a few autoimmune conditions and PC risk, albeit based on a relatively small number of cases. We conducted a population\u2010based, nested case\u2010control study to examine the associations between autoimmune conditions and PC risk within the Surveillance, Epidemiology, and End Results Program (SEER)\u2010Medicare population. Incident primary malignant PC cases (n\u00a0=\u00a080\u2009074) were adults \u226566\u2009years and diagnosed between 1992 and 2015. Controls (n\u00a0=\u00a0320\u2009296) were alive at the time cases were diagnosed and frequency\u2010matched to cases (4:1 ratio) by age, sex, and year of diagnosis. We used multivariable\u2010adjusted, unconditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 45 autoimmune conditions identified from Medicare claims. Eight autoimmune conditions including ankylosing spondylitis (OR\u00a0=\u00a01.45; 95% CI: 1.14\u20101.84), Graves' disease (OR\u00a0=\u00a01.18; 95% CI: 1.03\u20101.34), localized scleroderma (OR\u00a0=\u00a01.27; 95% CI: 1.06\u20101.52), pernicious anemia (OR\u00a0=\u00a01.08; 95% CI: 1.02\u20101.14), primary sclerosing cholangitis (OR\u00a0=\u00a01.37; 95% CI: 1.18\u20101.59), pure red cell aplasia (OR\u00a0=\u00a01.31; 95% CI: 1.16\u20101.47), type 1 diabetes (OR\u00a0=\u00a01.11; 95% CI: 1.07\u20101.15), and ulcerative colitis (OR\u00a0=\u00a01.18; 95% CI: 1.07\u20101.31) were associated with increased PC risk (false discovery rate\u2010adjusted <jats:italic>P<\/jats:italic> values &lt;.10). In subtype analyses, these conditions were associated with pancreatic ductal adenocarcinoma, whereas only ulcerative colitis was associated with pancreatic neuroendocrine tumors. Our results support the hypothesis that autoimmune conditions may play a role in PC development.<\/jats:p>","DOI":"10.1002\/ijc.34235","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T15:33:42Z","timestamp":1659368022000},"page":"172-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Autoimmune conditions and pancreatic cancer risk in older American adults"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-6754","authenticated-orcid":false,"given":"Fangcheng","family":"Yuan","sequence":"first","affiliation":[{"name":"Division Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7791-2698","authenticated-orcid":false,"given":"Ruth M.","family":"Pfeiffer","sequence":"additional","affiliation":[{"name":"Division Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sachelly","family":"Juli\u00e1n\u2010Serrano","sequence":"additional","affiliation":[{"name":"Division Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simran","family":"Arjani","sequence":"additional","affiliation":[{"name":"Division Cancer Epidemiology and Genetics, National Cancer Institute National Institutes of Health  Rockville Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Barrett","sequence":"additional","affiliation":[{"name":"Information Management Services, Inc.  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