{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:39:47Z","timestamp":1784119187733,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T00:00:00Z","timestamp":1662595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["ICMR\/EU\/13\/2012\/NCD\u2010III"],"award-info":[{"award-number":["ICMR\/EU\/13\/2012\/NCD\u2010III"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tobacco products are used in vary many forms in India. Although the risk of tobacco uses in developing head and neck cancer (HNC) is known, risk by exclusive use of different tobacco products on HNC and its subtypes is poorly understood. A case\u2010control study was conducted at a tertiary cancer hospital, which receives cases from different geographical regions of India with use of different types of tobacco products. The study included 824 oral cavity (OC), 149 oropharynx (OPX) 104 hypopharyngeal (HPX) and 81 larynx (LX) cancer cases and 1206 visitor controls. Information on 11 different types of tobacco products and exposure to secondhand smoke was collected through structured questionnaires. Odds ratios (OR) and 95% confidence intervals (CI), for the association of various HNC subtypes with exclusive use of each tobacco product compared to nonusers of tobacco were estimated using logistic regression models, after adjusting for potential confounders. Exclusive use of any type of smokeless tobacco product was strongly associated with all subtypes of HNC. <jats:italic>Gutka<\/jats:italic> chewing (only) had highest risk (OR\u00a0=\u00a033.67; 95% CI\u00a0=\u00a019.8\u201057.0) while exclusive users of betel quid with tobacco (BQ\u2009+\u2009T), tobacco quid, <jats:italic>Khaini<\/jats:italic>, <jats:italic>Mawa<\/jats:italic> and <jats:italic>Mishri<\/jats:italic> users had a OR of 14.77, 24.20, 5.33, 2.96 and 3.32, respectively, for development of OC. Bidi smoking and secondhand smoke was independently associated with increased risk of HNC. Our study indicates that tobacco control policies should focus on product specific awareness messaging that switching between tobacco product types is not a safe alternative to complete cessation.<\/jats:p>","DOI":"10.1002\/ijc.34258","type":"journal-article","created":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T12:35:08Z","timestamp":1661603708000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exclusive use of different types of tobacco products, exposure to secondhand tobacco smoke and risk of subtypes of head and neck cancer among Indian males"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6406-4562","authenticated-orcid":false,"given":"Devyani","family":"Gholap","sequence":"first","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genetics, Centre for Cancer Epidemiology Tata Memorial Centre  Navi Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4830-0486","authenticated-orcid":false,"given":"Rajesh","family":"Dikshit","sequence":"additional","affiliation":[{"name":"Division of Molecular Epidemiology and Population Genetics, Centre for Cancer Epidemiology Tata Memorial Centre  Navi Mumbai India"},{"name":"Homi Bhabha National Institute  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9795-7962","authenticated-orcid":false,"given":"Pankaj","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Homi Bhabha National Institute  Mumbai India"},{"name":"Head and Neck Oncology, Department of Surgical Oncology Tata Memorial Hospital  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Chaturvedi","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute, 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