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Change in the prevalence distribution of oncogenic HPV types that follows national HPV vaccination programs is setting the stage for loss of positive predictive value of conventional but possibly also new triage modalities. Understanding the contribution of the latter, most notably hypermethylation of cellular and viral genes in a new setting where most oncogenic HPV types are no longer present, requires studies on their performance in vaccinated women with CIN\/SIL that are associated with nonvaccine HPV types. Lessons learned from this research may highlight the potential of cervical cells for risk prediction of all women's cancers.<\/jats:p>","DOI":"10.1002\/ijc.34286","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T07:50:54Z","timestamp":1662969054000},"page":"1060-1068","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Assessing the risk of cervical neoplasia in the <scp>post\u2010HPV<\/scp> vaccination era"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9481-0535","authenticated-orcid":false,"given":"Matti","family":"Lehtinen","sequence":"first","affiliation":[{"name":"Medical Faculty Tampere University  Tampere Finland"},{"name":"Department of Laboratory Medicine Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0813-7031","authenticated-orcid":false,"given":"Ville N.","family":"Pimenoff","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Karolinska Institute  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Belinda","family":"Nedjai","sequence":"additional","affiliation":[{"name":"Wolfson Institute of Population Health Queen Mary University of London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Louvanto","sequence":"additional","affiliation":[{"name":"Medical Faculty Tampere University  Tampere Finland"},{"name":"Department of Obstetrics and Gynecology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9877-0297","authenticated-orcid":false,"given":"Lisanne","family":"Verhoef","sequence":"additional","affiliation":[{"name":"Department of Pathology Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Imaging and Biomarkers  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00eblle A. 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