{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:15:26Z","timestamp":1791238526322,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serrated polyps (SPs) are precursors to one\u2010third of colorectal cancers (CRCs), with histological subtypes: hyperplastic polyps (HPs), sessile serrated lesions (SSLs) and traditional serrated adenomas (TSAs). The incidence of early\u2010onset CRC before the age of 50 is increasing, with limited understanding of SPs in younger cohorts. Using a large colonoscopy\u2010based cohort, we characterized epidemiologic profiles of SP subtypes, compared to conventional adenomas, with secondary analysis on early\u2010onset polyps. Ninety\u2010four thousand four hundred and twenty\u2010seven patients underwent screening colonoscopies between 2010 and 2018. Demographic, endoscopic and histopathologic characteristics of each polyp subtype were described. High\u2010risk polyps included SSLs\u2009\u226510\u2009mm\/with dysplasia and conventional adenomas \u226510\u2009mm\/with tubulovillous\/villous histology\/high\u2010grade dysplasia. We examined polyp prevalence with age and compared early\u2010 (age\u2009&lt;\u200950) and late\u2010onset polyps (age\u2009\u2265\u200950). Eighteen thousand one hundred and twenty\u2010five patients had SPs (4357 SSLs, 15\u2009415 HPs, 120 TSAs) and 26\u2009699 had conventional adenomas. High\u2010risk SSLs were enriched in the ascending colon (44.1% vs 2.6\u201035.8% for other locations; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.003). Early\u2010 and late\u2010onset SPs had similar subsite distribution. Early\u2010onset conventional adenomas were more enriched in the distal colon\/rectum (51.8% vs 43.4%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). Multiple conventional adenomas were more represented in late\u2010onset groups (40.8% vs 33.8%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001), with no difference in SSLs. The prevalence of conventional adenomas\/high\u2010risk conventional adenomas increased continuously with age, whereas the prevalence of SSLs\/high\u2010risk SSLs was stable from age 40\u2009years onwards. A higher proportion of women were diagnosed with early\u2010onset than late\u2010onset SSLs (62.9% vs 57.6%, <jats:italic>P<\/jats:italic>\u00a0=\u2009.03). Conventional adenomas, SSLs, early\u2010 and late\u2010onset polyps have distinct epidemiology. The findings have implications for improved colonoscopy screening and surveillance and understanding the etiologic heterogeneity of CRC.<\/jats:p>","DOI":"10.1002\/ijc.34306","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T15:14:09Z","timestamp":1664550849000},"page":"1085-1094","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Epidemiology of overall and early\u2010onset serrated polyps versus conventional adenomas in a colonoscopy screening cohort"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1457-4385","authenticated-orcid":false,"given":"Mathew","family":"Vithayathil","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Nutrition Harvard T. H. 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