{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:38:24Z","timestamp":1790861904447,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,27]],"date-time":"2022-10-27T00:00:00Z","timestamp":1666828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["9039\u201000053B"],"award-info":[{"award-number":["9039\u201000053B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early studies reported a 4\u2010 to 6\u2010fold risk of breast cancer between women with extremely dense and fatty breasts. As most early studies were case\u2010control studies, we took advantage of a population\u2010based screening program to study density and breast cancer incidence in a cohort design. In the Capital Region, Denmark, women aged 50 to 69 are invited to screening biennially. Women screened November 2012 to December 2017 were included, and classified by BI\u2010RADS density code, version 4, at first screen after recruitment. Women were followed up for incident breast cancer, including ductal carcinoma in situ (DCIS), to 2020 in nationwide pathology data. Rate ratios (RRs) and 95% confidence intervals (CI) were compared across density groups using Poisson\u2010regression. We included 189\u2009609 women; 1\u2009067\u2009282 person\u2010years; and 4110 incident breast cancers\/DCIS. Thirty\u2010three percent of women had BI\u2010RADS density code 1; 38% code 2; 24% code 3; 4.7% code 4; and missing 0.3%. Using women with BI\u2010RADS density code 1 as baseline; women with code 2 had RR 1.69 (95% CI 1.56\u20101.84); women with code 3, RR 2.06 (95% CI 1.89\u20102.25); and women with code 4, RR 2.37 (95% CI 1.05\u20102.74). Results differed between observations accumulated during screening and above screening age. Our results indicated less difference in breast cancer risk across level of breast density than normally stated. Translated into absolute risk of breast cancer after age 50, we found a 6.2% risk for the one\u2010third of women with lowest density, and 14.7% for the 5% of women with highest density.<\/jats:p>","DOI":"10.1002\/ijc.34316","type":"journal-article","created":{"date-parts":[[2022,10,10]],"date-time":"2022-10-10T15:38:08Z","timestamp":1665416288000},"page":"1150-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Breast density and risk of breast cancer"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4785-5236","authenticated-orcid":false,"given":"Elsebeth","family":"Lynge","sequence":"first","affiliation":[{"name":"Nyk\u00f8bing Falster Hospital University of Copenhagen  Nyk\u00f8bing Falster Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse","family":"Vejborg","sequence":"additional","affiliation":[{"name":"Department of Breast Examinations Copenhagen University Hospital Gentofte  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lillholm","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mads","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Computer Science University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1197-2599","authenticated-orcid":false,"given":"George","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"My","family":"von Euler\u2010Chelpin","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.epi\u201006\u20100034"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/EdBook_AM.2013.33.e57"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe068244"},{"key":"e_1_2_12_5_1","unstructured":"BI\u2010RADS 4th ed. Accessed July 2 2018.http:\/\/www.radiologyassistant.nl\/en\/p53b4082c92130\/bi-rads-for-mammography-and-ultrasound-2013.html"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm8112021"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062790"},{"key":"e_1_2_12_8_1","unstructured":"Danish Quality Database for Breast Cancer Screening. Assessed April 8 2020.https:\/\/www.sundhed.dk\/content\/cms\/78\/4678_dkms_rapport_2019-(2).pdf"},{"key":"e_1_2_12_9_1","unstructured":"Danish Breast Cancer Group.Guidelines for Women With Concern About a Hereditary Risk of Breast Cancer[in Danish]. Accessed August 16 2022.https:\/\/www.dmcg.dk\/Kliniske-retningslinjer\/kliniske-retningslinjer-opdelt-paa-dmcg\/brystcancer\/arvelig-mammacancer--henvisningskriterier-til-genetisk-radgivning-indikation-for-tilbud-om-surveillance-og-profylaktisk-kirurgi\/"},{"key":"e_1_2_12_10_1","unstructured":"Danish Pathology Registration System. Accessed June 31 2021.https:\/\/www.patobank.dk\/snomed\/"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(07)70380-7"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.180.6.1801675"},{"key":"e_1_2_12_13_1","unstructured":"AccessedJuly 1 2021.https:\/\/wexnermedical.osu.edu\/blog\/facts-about-dense-breast-tissue"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju078"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010017\u20104274\u20109"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010021\u201001466\u2010y"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz149"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33138"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33661"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201017\u20101175"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010018\u20104864\u20101"},{"key":"e_1_2_12_22_1","unstructured":"AccessedJuly 1 2021.https:\/\/www\u2010dep.iarc.fr\/NORDCAN\/english\/Graph13l.asp?cancer=200&female=2&country%5B%5D=208&year=2016&year=2015&type=1&incidence=1&age_from=11&age_to=16&orientation=2&grid=1&line=2&submit=%A0%A0%A0Execute%A0%A0%A0"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.19.22275"},{"key":"e_1_2_12_24_1","unstructured":"AccessedDecember 12 2021.https:\/\/www.cancer.gov\/types\/breast\/breast-changes\/dense-breasts"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2021.04.013"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1903986"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djab119"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020201150"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.12783"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34316","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.34316","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T20:20:57Z","timestamp":1692476457000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,27]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,3,15]]}},"alternative-id":["10.1002\/ijc.34316"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34316","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,27]]},"assertion":[{"value":"2022-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}