{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:39:40Z","timestamp":1787063980092,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T00:00:00Z","timestamp":1666742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    In Denmark, vaccination against human papillomavirus (HPV) has been implemented in the children's vaccination program (January 2009) and in multiple catch\u2010up cohorts (October 2008 in girls 13\u201015\u2009years and in August 2012 in women up to 27\u2009years). In the present study we estimate incidence of cervical intraepithelial neoplasia grade 3 (CIN3), adenocarcinoma in situ (AIS), squamous cell carcinoma (SCC) and adenocarcinoma (AC) during 2000\u20102019. All cases of CIN3 and AIS were identified from the nationwide Pathology Data Bank, while SCC and AC were identified from the Danish Cancer Registry. We calculated age\u2010standardized incidence rates and estimated annual percentage change (EAPC) with corresponding 95% confidence interval (CI) for the periods before vaccination implementation (2000\u20102005), early after implementation of childhood HPV vaccination and the first catch\u2010up vaccination program (2006\u20102012), and after implementation of the second catch\u2010up program (2013\u20102019). For CIN3 and AIS, age\u2010specific incidence rates and EAPCs were calculated. An increasing age\u2010standardized incidence was observed before introduction of HPV vaccination (2000\u20102005) for CIN3 [EAPC\n                    <jats:sub>CIN3<\/jats:sub>\n                    : 3.0 (95% CI 1.7 to 4.3)] and AIS [EAPC\n                    <jats:sub>AIS<\/jats:sub>\n                    : 3.5 (95% CI 0.7 to 6.4)]. In the most recent period (2013\u20102019), following implementation of the second catch\u2010up program, a decrease was observed for both CIN3 [EAPC\n                    <jats:sub>CIN3<\/jats:sub>\n                    : \u20106.5 (95% CI \u20108.3 to \u22124.8)], AIS [EAPC\n                    <jats:sub>AIS<\/jats:sub>\n                    : \u20108.7 (95% CI \u201012.3 to \u22125.1)] and for SCC [EAPC\n                    <jats:sub>SCC<\/jats:sub>\n                    : \u20103.9 (95% CI \u20107.5 to \u22120.2)]. In this study we document a decrease in the incidence of CIN3, AIS and SCC in the period after implementation of multi\u2010cohort HPV vaccination in Denmark.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34328","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T05:00:54Z","timestamp":1665982854000},"page":"1320-1327","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Incidence of cervical precancerous lesions and cervical cancer in Denmark from 2000 to 2019: Population impact of multi\u2010cohort vaccination against human papillomavirus infection"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7149-8908","authenticated-orcid":false,"given":"Linea Landgrebe","family":"Ring","sequence":"first","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Munk","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Galanakis","sequence":"additional","affiliation":[{"name":"Statistics, Bioinformatics and Registry Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Tota","sequence":"additional","affiliation":[{"name":"Merck &amp; Co., Inc.  Rahway New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0738-8410","authenticated-orcid":false,"given":"Louise T.","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne K.","family":"Kjaer","sequence":"additional","affiliation":[{"name":"Unit of Virus, Lifestyle and Genes Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Gynecology Copenhagen University Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2020.11754"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14276"},{"key":"e_1_2_10_5_1","first-page":"S2","article-title":"Epidemiology and natural history of genital human papillomavirus infection","volume":"106","author":"Weaver BA","year":"2006","journal-title":"J Am Osteopath Assoc"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.362"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2017.1355110"},{"key":"e_1_2_10_8_1","unstructured":"Sundhedsstyrelsen.https:\/\/www.sst.dk\/da\/viden\/screening\/screening-for-kraeft\/livmoderhalskraeft. 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