{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:06:01Z","timestamp":1793829961618,"version":"4.6.1"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T00:00:00Z","timestamp":1670371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00001"],"award-info":[{"award-number":["75N92021D00001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00002"],"award-info":[{"award-number":["75N92021D00002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00003"],"award-info":[{"award-number":["75N92021D00003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00004"],"award-info":[{"award-number":["75N92021D00004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00005"],"award-info":[{"award-number":["75N92021D00005"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,4,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epidemiologic evidence is limited about associations between T2DM, metformin, and the risk of non\u2010Hodgkin's lymphoma (NHL). We aimed to examine associations between T2DM, metformin, and the risk of NHL in the Women's Health Initiative (WHI) Study. Information on T2DM status (diabetes status\/types of antidiabetic drug use\/diabetes duration) from study enrollment and during follow\u2010up were assessed. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to evaluate associations of T2DM status with risks of overall NHL and its three major subtypes [diffuse large B\u2010cell lymphoma (DLBCL, n\u00a0=\u00a0476), follicular lymphoma (FL, n\u00a0=\u00a0301) and chronic lymphocytic leukemia\/small lymphocytic lymphoma (CLL\/SLL, n\u00a0=\u00a0136)] based on multivariable\u2010adjusted Cox proportional hazards models. During a median follow\u2010up of 18.86\u2009years (range, 0.01\u201025.13; SD\u2009\u00b1\u20096.55), a total of 1637 women developed NHL among 147\u2009885 postmenopausal women. Women with T2DM and with self\u2010reported oral medication use had 38% and 55% higher risk of DLBCL, respectively [multivariable\u2010adjusted model HR\u00a0=\u00a01.38, 95% CI (1.06\u20101.81) and HR\u00a0=\u00a01.55, 95% CI (1.16\u20102.06)] compared to the reference group (nondiabetics\/untreated diabetes). Risks of NHL and DLBCL [multivariable\u2010adjusted model: HR\u00a0=\u00a01.28, 95% CI (1.06\u20101.54) and HR\u00a0=\u00a01.56, 95% CI (1.13\u20102.14), respectively] were significantly higher in associations with relatively short duration (\u22647\u2009years) of diabetes, compared to reference group. Additionally, an increased risk of DLBCL [HR\u00a0=\u00a01.76, 95% CI (1.13\u20102.75)] was found in metformin users compared to the reference group. Postmenopausal women who had T2DM, who were oral antidiabetic drug users, especially metformin, and who had a shorter diabetes duration may have higher risks of DLBCL. Further well\u2010designed research is needed to confirm our findings.<\/jats:p>","DOI":"10.1002\/ijc.34376","type":"journal-article","created":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T08:43:30Z","timestamp":1669711410000},"page":"1556-1569","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Diabetes, metformin use and risk of non\u2010<scp>Hodgkin's<\/scp> lymphoma in postmenopausal women: A prospective cohort analysis in the Women's Health Initiative"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7673-3927","authenticated-orcid":false,"given":"Zikun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence S.","family":"Phillips","sequence":"additional","affiliation":[{"name":"Atlanta VA Medical Center  Decatur Georgia USA"},{"name":"Division of Endocrinology Emory University School of Medicine  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria Y. F.","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aladdin H.","family":"Shadyab","sequence":"additional","affiliation":[{"name":"Herbert Wertheim School of Public Health and Human Longevity Science University of California, San Diego  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurelian","family":"Bidulescu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Rudick","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Medical Sciences Program Indiana University School of Medicine\u2010Bloomington  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Pan","sequence":"additional","affiliation":[{"name":"Division of Research Kaiser Permanente Northern California  Oakland California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongxue","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Statistics, College of Arts, Sciences and Education Florida International University  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-4462","authenticated-orcid":false,"given":"Juhua","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Indiana University Bloomington  Bloomington Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,12,7]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"SEER Cancer Stat Facts: Non\u2010Hodgkin Lymphoma","author":"National Cancer Institute, Bethesda","year":"2021"},{"key":"e_1_2_13_3_1","volume-title":"Guidelines\u00ae. Clinical Practice Guidelines in Oncology","author":"NCCN","year":"2019"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-019-01155-5"},{"key":"e_1_2_13_5_1","volume-title":"SEER Cancer Statistics Review, 1975\u20132003","author":"Ries LA","year":"2006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29792"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2012.673225"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690547"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90177-5"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860500531682"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3515-2"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-10-119974"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr167"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32576"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-009-0551-2"},{"key":"e_1_2_13_16_1","volume-title":"CDC National Diabetes Statistics Report 2020: estimates of diabetes and its burden in the United States","author":"Control CFD and Prevention","year":"2021"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.3.867S"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/789174"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-06-362830"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.12297"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160709300101"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1262-3636(03)72785-2"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199958001-00009"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0012"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(97)00078-0"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00047-4"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00043-7"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwv446"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774508091749"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(03)00048-6"},{"key":"e_1_2_13_31_1","first-page":"2375","article-title":"The 2016 revision of the World Health Organization classification of lymphoid neoplasms","volume":"127","author":"Swerdlow SH","year":"2016","journal-title":"Blood, the Journal of the American Society of Hematology"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008265532487"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.309.6964.1269"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/89.4.314"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr334"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.04.006"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1034"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/16078454.2019.1636485"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i3.372"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.08.004"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3215"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2014.2341"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.04.013"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-1791"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-009-9407-y"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2011.574752"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15997"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.05.002"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.5772\/intechopen.88675"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-05-0918"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-814147"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ijc.34376","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T19:34:57Z","timestamp":1692560097000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,7]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,4,15]]}},"alternative-id":["10.1002\/ijc.34376"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34376","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,7]]},"assertion":[{"value":"2022-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}