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However, lately published in vitro data possibly indicates a DM\u2010induced suppression of oncogene\u2010induced senescence (OIS) in a preclinical pediatric low\u2010grade glioma (pLGG) model, which, alongside data associating perioperative DM treatment with reduced event\u2010free survival in adult glioma, raises questions concerning the safety of DM treatment in pLGG. A total of 172 patients with pLGG were retrospectively analyzed concerning the impact of perioperative DM application on postoperative short\u2010 and long\u2010term tumor growth velocity and progression\u2010free survival (PFS). Three\u2010dimensional volumetric analyses of sequential MRI follow\u2010up examinations were used for assessment of tumor growth behavior. Mean follow\u2010up period accounted for 60.1\u00a0months. Sixty\u2010five patients (45%) were perioperatively treated with DM in commonly used doses. Five\u2010year PFS accounted for 93% following gross\u2010total resection (GTR) and 57% post incomplete resection (IR). Comparison of short\u2010 and long\u2010term postoperative tumor growth rates in patients with vs without perioperative DM application showed no significant difference (short\u2010term: 0.022 vs 0.023\u2009cm<jats:sup>3<\/jats:sup>\/month, respectively; long\u2010term: 0.019 vs 0.023\u2009cm<jats:sup>3<\/jats:sup>\/month, respectively). Comparison of PFS post IR (5\u2010year\u2010PFS: 65% vs 55%, respectively; 10\u2010year\u2010PFS: 52% vs 53%, respectively) and GTR (5\u2010 and 10\u2010years\u2010PFS: 91% vs 92%, respectively) likewise showed similarity. This data emphasizes the safety of perioperative DM application in pLGG, adding further evidence for decision making and requested future guidelines.<\/jats:p>","DOI":"10.1002\/ijc.34399","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T05:20:22Z","timestamp":1671168022000},"page":"1875-1883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the safety of perioperative dexamethasone treatment: A retrospective analysis of a single center pediatric low\u2010grade glioma cohort"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7311-5840","authenticated-orcid":false,"given":"David","family":"Gorodezki","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology University Children's Hospital T\u00fcbingen  T\u00fcbingen 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