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could contribute to colorectal cancer development and progression due to their pro\u2010oxidative and pro\u2010inflammatory properties. However, the association of glycer\u2010AGEs with mortality after colorectal cancer diagnosis has not been previously investigated. Circulating glycer\u2010AGEs were measured by competitive ELISA. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs) for associations of circulating glycer\u2010AGEs concentrations with CRC\u2010specific and all\u2010cause mortality among 1034 colorectal cancer (CRC) cases identified within the European Prospective Investigation into Cancer and Nutrition (EPIC) study between 1993 and 2013. During a mean of 48\u2009months of follow\u2010up, 529 participants died (409 from CRC). Glycer\u2010AGEs were statistically significantly positively associated with CRC\u2010specific (HR<jats:sub>Q5 vs Q1<\/jats:sub>\u00a0=\u20091.53, 95% CI: 1.04\u20102.25, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0=\u2009.002) and all\u2010cause (HR<jats:sub>Q5 vs Q1<\/jats:sub>\u00a0=\u20091.62, 95% CI: 1.16\u20102.26, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u00a0&lt;\u2009.001) mortality among individuals with CRC. There was suggestion of a stronger association between glycer\u2010AGEs and CRC\u2010specific mortality among patients with distal colon cancer (per SD increment: HR<jats:sub>proximal colon<\/jats:sub>\u00a0=\u20091.02, 95% CI: 0.74\u20101.42; HR<jats:sub>distal colon<\/jats:sub>\u00a0=\u20091.51, 95% CI: 1.20\u20101.91; <jats:italic>P<\/jats:italic><jats:sub>effect modification<\/jats:sub>\u00a0=\u2009.02). The highest HR was observed among CRC cases in the highest body mass index (BMI) and glycer\u2010AGEs category relative to lowest BMI and glycer\u2010AGEs category for both CRC\u2010specific (HR\u00a0=\u00a01.78, 95% CI: 1.02\u20103.01) and all\u2010cause mortality (HR\u00a0=\u00a02.15, 95% CI: 1.33\u20103.47), although no statistically significant effect modification was observed. Our study found that prediagnostic circulating glycer\u2010AGEs are positively associated with CRC\u2010specific and all\u2010cause mortality among individuals with CRC. Further investigations in other populations and stratifying by tumor location and BMI are warranted.<\/jats:p>","DOI":"10.1002\/ijc.34449","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T12:49:41Z","timestamp":1675082981000},"page":"2257-2268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Prediagnostic serum glyceraldehyde\u2010derived advanced glycation end products and mortality among colorectal cancer patients"],"prefix":"10.1002","volume":"152","author":[{"given":"Ziling","family":"Mao","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"},{"name":"Department of Epidemiology, Graduate School of Public Health University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline Roshelli","family":"Baker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine Medical Research Institute, Kanazawa Medical University  Ishikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Hyogo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Hiroshima University Hospital  Hiroshima Japan"},{"name":"Lifecare Clinic Hiroshima  Hiroshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center, Diet, Cancer and Health  Copenhagen Denmark"},{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kirstine","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center, Diet, Cancer and Health  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-419X","authenticated-orcid":false,"given":"Gianluca","family":"Severi","sequence":"additional","affiliation":[{"name":"UVSQ, Inserm, Centre for Epidemiology and Population Health (U1018), Exposome and Heredity Team Universit\u00e9 Paris\u2010Saclay  Villejuif France"},{"name":"Department of Statistics, Computer Science Applications \u201cG. 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