{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:44:25Z","timestamp":1793742265763,"version":"4.6.1"},"reference-count":47,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,2,28]],"date-time":"2023-02-28T00:00:00Z","timestamp":1677542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Fatigue is a common symptom experienced by 80% of individuals who receive chemotherapy and is one of the major factors that affect quality of life (QoL) of patients with breast cancer. Our study aimed to assess the effect of cognitive behavioural therapy integrated with activity pacing (CBT\u2010AP) on cancer\u2010related fatigue among patients with breast cancer undergoing chemotherapy. A parallel\u2010group, randomised controlled trial was conducted. Severely fatigued patients were randomly assigned to the CBT\u2010AP or usual care (UC) groups using a computer\u2010generated random sequence. The new intervention was designed for seven sessions: three 2\u2010hour face\u2010to\u2010face and four 30\u2010minute telephone sessions. The primary outcome (fatigue severity) and the secondary outcomes (depression and QoL) were assessed at the end of the intervention and after 3\u00a0months. The data were analysed by repeated measures analyses of covariance (RM\u2010ANCOVA). CBT\u2010AP had a significant time effect (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009&lt;\u2009.001,\n                    <jats:italic>\u03b7p<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    \u00a0=\u00a00.233) in reducing fatigue from baseline (adjusted mean\u00a0=\u00a07.48) to the end of the intervention (adjusted mean\u00a0=\u00a06.37) and the 3\u2010month follow\u2010up (adjusted mean\u00a0=\u00a06.54). Compared to the UC group, the CBT\u2010AP group had lower fatigue and depression scores, and higher global health status scores. The group \u00d7 time interaction revealed a significant reduction in fatigue and depression in the CBT\u2010AP group compared to the UC group. Therefore, CBT\u2010AP appears to be effective in reducing fatigue and depression and improving QoL in patients with breast cancer undergoing chemotherapy. It is highly recommended to integrate a CBT\u2010AP intervention in routine cancer care.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34452","type":"journal-article","created":{"date-parts":[[2023,2,6]],"date-time":"2023-02-06T04:48:46Z","timestamp":1675658926000},"page":"2541-2553","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The effect of cognitive behavioural therapy integrated with activity pacing on cancer\u2010related fatigue, depression and quality of life among patients with breast cancer undergoing chemotherapy in Ethiopia: A randomised clinical trial"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7752-4855","authenticated-orcid":false,"given":"Mikiyas Amare","family":"Getu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"School of Nursing and Health Zhengzhou University  Zhengzhou China"},{"name":"School of Nursing Woldia University  Woldia Ethiopia"},{"name":"Global Health Working Group Martin\u2010Luther\u2010University Halle\u2010Wittenberg  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panpan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Nursing and Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adamu","family":"Addissie","sequence":"additional","affiliation":[{"name":"Institute of Medical Epidemiology, Biostatistics and Informatics Martin\u2010Luther\u2010University  Halle (Saale) Germany"},{"name":"School of Public Health, Department of Preventive Medicine, College of Health Sciences Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edom","family":"Seife","sequence":"additional","affiliation":[{"name":"Tikur Anbessa Specialized Hospital, Department of Oncology, College of Health Science Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changying","family":"Chen","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"},{"name":"School of Nursing and Health Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Johanna","family":"Kantelhardt","sequence":"additional","affiliation":[{"name":"Institute of Medical Epidemiology, Biostatistics and Informatics Martin\u2010Luther\u2010University  Halle (Saale) Germany"},{"name":"Department of Gynecology Martin\u2010Luther\u2010University  Halle (Saale) Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,28]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","unstructured":"International Agency for Research on Cancer: World Health Organization.The Global Cancer Observatory: Ethiopia; 2021:1\u20102.https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/231-ethiopia-fact-sheetsAccessed January 4 2022."},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2018.01.008"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05398-w"},{"issue":"9","key":"e_1_2_12_6_1","first-page":"1","article-title":"Quality of life and associated factors among patients with breast cancer under chemotherapy at Tikur Anbessa specialized hospital, Addis Ababa, Ethopia","volume":"14","author":"Mohammed A","year":"2019","journal-title":"PLoS One"},{"issue":"8","key":"e_1_2_12_7_1","first-page":"1012","article-title":"Cancer\u2010related fatigue","volume":"13","author":"Murphy BA","year":"2015","journal-title":"J Natl Compr Canc Netw"},{"issue":"17","key":"e_1_2_12_8_1","first-page":"2","article-title":"Cancer\u2010related fatigue: causes and current treatment options","volume":"211","author":"Thong MSY","year":"2020","journal-title":"Curr Treat Options Oncol"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2021.585534"},{"key":"e_1_2_12_10_1","first-page":"1","article-title":"Depression and anxiety in patients with cancer","volume":"361","author":"Pitman A","year":"2018","journal-title":"BMJ"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6007-4"},{"key":"e_1_2_12_12_1","unstructured":"BergerAM MooneyK BanerjeeC BreitbartWS.NCCN Clinical Practice Guidelines in Oncology Cancer\u2010Related Fatigue. 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