{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T14:24:44Z","timestamp":1781706284033,"version":"3.54.5"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adjuvant immunotherapy (IO) and targeted therapy (TT) have improved relapse\u2010free survival (RFS) in patients with stage III melanoma, although about 25% of them relapse within a year. However, real\u2010world data on treatment efficacy and safety as well as management of treatment recurrences are still limited. We retrospectively analyzed 113 patients with stage III melanoma who received at least one cycle of anti\u2010PD\u20101 (nivolumab or pembrolizumab) or dabrafenib + trametinib as adjuvant therapy. Most of patients included into the analyses harbor <jats:italic>BRAV600E<\/jats:italic> mutation (66.4%) and had a stage IIIC melanoma (63.7%). Immunotherapy was administered in 48.7% of patients, whereas targeted therapy in 51.3% At data cut\u2010off, median RFS was not reached with 12\u2010 and 24\u2010months RFS of 81% and 64%, respectively. No new adverse events were registered. Thirty patients (26.5%) relapsed, mainly at distant sites. Patient treated with IO recurred mostly during adjuvant treatment (ON\u2010treatment) while patients treated with TT relapsed at the end of treatment (OFF\u2010treatment). At relapse, surgery, radiotherapy and systemic therapy were used alone or in combination. Among patients who started a first\u2010line therapy, an excellent response switching to a different treatment was observed. Real\u2010world outcomes and safety of adjuvant treatment for resected stage III melanoma appear comparable to clinical trials data. Moreover, management of recurrences depends on type of relapse (loco\u2010regional vs distant) and timing (during vs OFF treatment). Furthermore, patients who relapse after adjuvant TT respond well to subsequent anti\u2010PD1 based therapy.<\/jats:p>","DOI":"10.1002\/ijc.34462","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T13:44:39Z","timestamp":1675863879000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Real\u2010world clinical outcome and safety of adjuvant therapy in stage <scp>III<\/scp> melanoma patients: Data from two Academic Italian Institutions"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0261-0382","authenticated-orcid":false,"given":"Vincenzo","family":"De Falco","sequence":"first","affiliation":[{"name":"Medical Oncology, Department of Precision Medicine Universit\u00e0 degli Studi della Campania \u201cLuigi Vanvitelli\u201d  Naples Italy"},{"name":"Department of Experimental Medicine, Section of Biotechnology, Molecular Medicine and Medical Histology University of Campania \u201cL. 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