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We conducted a nationwide case\u2010control study in Sweden among 69\u2009659 CRC cases and 343\u2009032 non\u2010CRC controls matched on age, sex, birth year and residence county. Through linkage of multi\u2010generation register and the nationwide ESPRESSO (Epidemiology Strengthened by histoPathology Reports in Sweden) cohort, we ascertained IBD diagnoses among parents, full siblings and offspring of the index individuals. Odds ratios (ORs) of CRC associated with IBD family history were calculated using conditional logistic regression. 2.2% of both CRC cases (1566\/69659) and controls (7676\/343027) had \u22651 FDR with IBD history. After adjusting for family history of CRC, we observed no increased risk of CRC in FDRs of IBD patients (OR, 0.96; 95%CI, 0.91\u20101.02). The null association was consistent according to IBD subtype (Crohn's disease or ulcerative colitis), number of FDRs with IBD (1 or\u2009\u2265\u20092), age at first IBD diagnosis in FDRs (&lt;18, 18\u201039, 40\u201059 or \u226560\u2009years), maximum location\/extent of IBD or FDR relation (parent, sibling or offspring). The null association remained for early\u2010onset CRC (diagnosed at age &lt;50\u2009years). In conclusion, IBD history in FDRs was not associated with an increased risk of CRC. Our findings suggest that extra screening for CRC may not be needed in the offspring, siblings or parents of IBD patients, and strengthen the theory that it is the actual inflammation or atypia of the colon in IBD patients that confers the increased CRC risk.<\/jats:p>","DOI":"10.1002\/ijc.34470","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T07:35:11Z","timestamp":1676014511000},"page":"2303-2313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of inflammatory bowel disease in first\u2010degree relatives with risk of colorectal cancer: A nationwide case\u2010control study in Sweden"],"prefix":"10.1002","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5614-5618","authenticated-orcid":false,"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology Harvard T.H. 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