{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T23:57:37Z","timestamp":1781049457099,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Few clinical trials address efficacy of adjuvant systemic treatment in patients with in\u2010transit melanoma (ITM). This study describes adjuvant systemic therapy of ITM patients beyond clinical trials. In this study, we included stage III adjuvant\u2010treated melanoma patients registered in the nationwide Dutch Melanoma Treatment Registry between July 2018 and December 2020. Patients were divided into three groups: nodal disease only, ITM only and ITM and nodal disease. Recurrence patterns, recurrence\u2010free survival (RFS) and overall survival (OS) at 12\u2010months were analyzed. In our study population of 1037 patients, 66.8% had nodal disease only, 16.7% had ITM only and 16.2% had ITM with nodal disease. RFS at 12\u2010months was comparable in the nodal only and ITM only group (72.2% vs70.1%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.97) but lower in ITM and nodal disease patients (57.8%;<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Locoregional metastases occurred as first recurrence in 38.9% nodal disease only, 71.9% of ITM\u2010only and 44.0% of ITM and nodal disease patients. Distant recurrences occurred in 42.3%, 18.8% and 36.0%, respectively (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.02). 12\u2010months OS was not significantly different for nodal disease only patients compared with ITM\u2010only (94.4% vs 97.6%,<jats:italic>P<\/jats:italic>\u00a0=\u00a0.06) but was significantly higher for ITM\u2010only compared with ITM and nodal disease patients (97.6% vs 91.0%,<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). In conclusion, we showed that in the adjuvant setting, RFS rates in ITM\u2010only patients are similar to non\u2010ITM, though better than in ITM and nodal disease patients. Adjuvant\u2010treated ITM\u2010only patients less often experience distant recurrences and have a superior OS compared with ITM and nodal disease patients.<\/jats:p>","DOI":"10.1002\/ijc.34485","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T05:23:18Z","timestamp":1677475398000},"page":"389-398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adjuvant treatment of in\u2010transit melanoma: Narrowing the knowledge gap left by clinical trials"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1306-2713","authenticated-orcid":false,"given":"Melissa M.","family":"de Meza","sequence":"first","affiliation":[{"name":"Dutch Institute for Clinical Auditing Leiden The Netherlands"},{"name":"Department of Biomedical Data Sciences Leiden University Medical Center Leiden The Netherlands"},{"name":"Department of Surgical Oncology Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4647-8830","authenticated-orcid":false,"given":"Willeke A. 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