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These carcinomas originate in epithelia lining the mouth, proximal esophagus, vulva and anus: their origins are not understood, and no effective ways have been identified to prevent or delay their appearance. Many FA\u2010associated carcinomas are also therapeutically challenging: they may be multi\u2010focal and stage\u2010advanced at diagnosis, and most individuals with FA cannot tolerate standard\u2010of\u2010care systemic therapies such as DNA cross\u2010linking drugs or ionizing radiation due to constitutional DNA damage hypersensitivity. We developed the Fanconi Anemia Cancer Cell Line Resource (FA\u2010CCLR) to foster new work on the origins, treatment and prevention of FA\u2010associated carcinomas. The FA\u2010CCLR consists of Fanconi\u2010isogenic head and neck squamous cell carcinoma (HNSCC) cell line pairs generated from five individuals with FA\u2010associated HNSCC, and five individuals with sporadic HNSCC. Sporadic, isogenic HNSCC cell line pairs were generated in parallel with FA patient\u2010derived isogenic cell line pairs to provide comparable experimental material to use to identify cell and molecular phenotypes driven by germline or somatic loss of Fanconi pathway function, and the subset of these FA\u2010dependent phenotypes that can be modified, complemented or suppressed. All 10\n                    <jats:italic>FANC<\/jats:italic>\n                    \u2010isogenic cell line pairs are available to academic, non\u2010profit and industry investigators via the \u201cFanconi Anemia Research Materials\u201d Resource and Repository at Oregon Health &amp; Sciences University, Portland OR.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34506","type":"journal-article","created":{"date-parts":[[2023,3,13]],"date-time":"2023-03-13T07:30:56Z","timestamp":1678692656000},"page":"183-196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fanconi anemia\u2010isogenic head and neck cancer cell line pairs: A basic and translational science resource"],"prefix":"10.1002","volume":"153","author":[{"given":"Hiep Tai","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiliang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L. 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