{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:43:46Z","timestamp":1790293426281,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T00:00:00Z","timestamp":1681862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U22A20359"],"award-info":[{"award-number":["U22A20359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874283"],"award-info":[{"award-number":["81874283"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673255"],"award-info":[{"award-number":["81673255"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To comprehensively evaluate the etiological role of ABO blood group in human cancer, we conducted a large\u2010scale meta\u2010analysis of 127 publications totaling 20 million participants including 231\u2009737 patients of 20 cancers, supplemented by genetic evidence. Effects of A, AB and B groups on cancer risk were investigated by respectively comparing with O group and their combined counterparts, and subgroup analysis by ethnicity was conducted for O\u2010referent models. For cancer categories, A group increased risk of cancers of oral cavity and nasopharynx, digestive and female genital organs, while both AB and B groups showed associations with cancers of digestive and female genital organs. For individual cancers, A group significantly increased the risk of nine cancers including oral cavity (OR\u2009=\u20091.17, <jats:italic>P<\/jats:italic>\u2009=\u2009.013), stomach (OR\u2009=\u20091.19, <jats:italic>P<\/jats:italic>\u2009=\u20093.90\u2009\u00d7\u200910<jats:sup>\u221215<\/jats:sup>), pancreas (OR\u2009=\u20091.33, <jats:italic>P<\/jats:italic>\u2009=\u20099.89\u2009\u00d7\u200910<jats:sup>\u221233<\/jats:sup>), colorectum (OR\u2009=\u20091.09, <jats:italic>P<\/jats:italic>\u2009=\u2009.001), liver (OR\u2009=\u20091.23, <jats:italic>P<\/jats:italic>\u2009=\u2009.011), ovary (OR\u2009=\u20091.13, <jats:italic>P<\/jats:italic>\u2009=\u2009.001), cervix (OR\u2009=\u20091.17, <jats:italic>P<\/jats:italic>\u2009=\u2009.025), bladder (OR\u2009=\u20091.12, <jats:italic>P<\/jats:italic>\u2009=\u2009.025) and breast (OR\u2009=\u20091.06, <jats:italic>P<\/jats:italic>\u2009=\u2009.043). AB group showed associations with only three cancers: stomach (OR\u2009=\u20091.10, <jats:italic>P<\/jats:italic>\u2009=\u2009.007), pancreas (OR\u2009=\u20091.21, <jats:italic>P<\/jats:italic>\u2009=\u2009.001) and ovary (OR\u2009=\u20091.28, <jats:italic>P<\/jats:italic>\u2009=\u2009.006). B group, except for shared associations with A group on pancreas (OR\u2009=\u20091.20, <jats:italic>P<\/jats:italic>\u2009=\u20092.27\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>) and cervix cancers (OR\u2009=\u20091.13, <jats:italic>P<\/jats:italic>\u2009=\u2009.011), had two distinct associations with esophagus (OR\u2009=\u20091.17, <jats:italic>P<\/jats:italic>\u2009=\u2009.002) and nonmelanoma skin cancers (OR\u2009=\u20090.96, <jats:italic>P<\/jats:italic>\u2009=\u2009.017). Ethnicity\u2010specific analyses revealed the notable effects of non\u2010O groups on pancreatic cancer both in Caucasians and Asians. In genetic analysis, four SNPs were associated with the risk of pancreatic cancer, with rs505922 corresponding to O group showing the strongest protective effect (<jats:italic>P<\/jats:italic>\u2009=\u20091.16\u2009\u00d7\u200910<jats:sup>\u221223<\/jats:sup>). Our study provided comprehensive evidence of ABO blood group associated with cancers and highlighted its carcinogenic role.<\/jats:p>","DOI":"10.1002\/ijc.34533","type":"journal-article","created":{"date-parts":[[2023,4,19]],"date-time":"2023-04-19T14:39:07Z","timestamp":1681915147000},"page":"320-330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Epidemiological and genetic evidence for the relationship between <scp>ABO<\/scp> blood group and human cancer"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1289-3179","authenticated-orcid":false,"given":"Huijie","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peijing","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health and Management Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health and Management Chongqing Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingshuang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghan","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Maternal, Child and Adolescent Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Iatrical Polymer Material and Artificial Apparatus, School of Polymer Science and Engineering Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. Chen Institute of Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Health, West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-1637","authenticated-orcid":false,"given":"Jiayuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, Institute of Systems Epidemiology, and West China\u2010PUMC C. C. 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