{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:57:42Z","timestamp":1780466262711,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T00:00:00Z","timestamp":1682726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007435","name":"\u00c5ke Wiberg Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007435","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Childbirth rates in classical Hodgkin lymphoma (cHL) survivors have historically been reduced compared to the general population. Understanding if contemporary treatment protocols are associated with reduced fertility is crucial as treatment guidelines shift toward more liberal use of intensive chemotherapy. We identified 2834 individuals aged 18\u201040\u2009years with cHL in Swedish and Danish lymphoma registers, and in the clinical database at Oslo University Hospital diagnosed 1995\u20102018, who were linked to national medical birth registers. Cox regression adjusted for stage, performance status, year, and age at diagnosis was used to estimate hazard ratios (HRs) and 95% confidence intervals (CI) contrasting time to first childbirth by treatment groups (ABVD, 2\u20104 BEACOPP, 6\u20108 BEACOPP) up to 10\u2009years after diagnosis. Overall, 74.8% of patients were treated with ABVD, 3.1% with 2\u20104 BEACOPP and 11.2% with 6\u20108 BEACOPP. Adjusted HRs comparing childbirth rates in individuals treated with 6\u20108 BEACOPP, and 2\u20104 BEACOPP to ABVD were 0.53 (CI: 0.36\u20100.77) and 0.33 (CI: 0.12\u20100.91) for males, and 0.91 (CI: 0.61\u20101.34) and 0.38 (CI: 0.12\u20101.21) for females. Cumulative incidence of childbirths after 10\u2009years was 19.8% (CI: 14.5%\u201027.0%) for males and 34.3% (CI: 25.8%\u201045.6%) for females treated with 6\u20108 BEACOPP. Proportions of children born after assisted reproductive technique (ART) treatments were 77.4% (CI: 60.2\u201088.6%) for males following 6\u20108 BEACOPP, and\u2009&lt;11% for females. Among ABVD treated patients the corresponding proportions were 12.2% (CI: 8.5%\u201017.3%) and 10.6% (CI: 7.4%\u201014.9%). BEACOPP treatment is associated with decreased childbirth rates compared to ABVD in male, but not female, cHL patients, despite widespread access to ART in the Nordics.<\/jats:p>","DOI":"10.1002\/ijc.34552","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T05:58:36Z","timestamp":1682747916000},"page":"723-731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Reproduction patterns among classical Hodgkin lymphoma survivors treated with\n                    <scp>BEACOPP<\/scp>\n                    and\n                    <scp>ABVD<\/scp>\n                    in Sweden, Denmark and Norway\u2014A population\u2010based matched cohort study"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-8096","authenticated-orcid":false,"given":"Joshua P.","family":"Entrop","sequence":"first","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8231-8183","authenticated-orcid":false,"given":"Caroline E.","family":"Weibull","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin E.","family":"Smedby","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Hematology Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse H.","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Mathematical Science Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4631-9936","authenticated-orcid":false,"given":"Andreas K.","family":"\u00d8vlisen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Cancer Research Center Aalborg University Hospital  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Molin","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6158-3041","authenticated-orcid":false,"given":"Ingrid","family":"Glimelius","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"},{"name":"Department of Immunology, Genetics and Pathology, Unit of Experimental and Clinical Oncology Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9131-7040","authenticated-orcid":false,"given":"Anna","family":"Marklund","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Division of Gynecology and Reproduction Karolinska University Hospital  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9799-9428","authenticated-orcid":false,"given":"Harald","family":"Holte","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4484-9319","authenticated-orcid":false,"given":"Alexander","family":"Foss\u00e5","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University 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Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-0573","authenticated-orcid":false,"given":"Sandra","family":"Eloranta","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology Division, Department of Medicine Solna Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,29]]},"reference":[{"key":"e_1_2_12_2_1","article-title":"Comparison of first\u2010line chemotherapy including escalated BEACOPP versus chemotherapy including ABVD for people with early unfavourable or advanced stage Hodgkin lymphoma","volume":"5","author":"Skoetz N","year":"2017","journal-title":"Cochrane Database Syst 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