{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T11:02:31Z","timestamp":1764414151575,"version":"3.46.0"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T00:00:00Z","timestamp":1683590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16H06277","21H04824","22H04923"],"award-info":[{"award-number":["16H06277","21H04824","22H04923"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55\u2009242 participants (median age, 57\u2009years; 55% women) from the Japan Multi\u2010Institutional Collaborative Cohort Study. We also investigated differences in cancer risk factors between individuals with and without kidney dysfunction. During a median 9.3\u2010year follow\u2010up period, 4278 (7.7%) subjects developed cancer. Moderately low and high eGFRs were associated with higher cancer incidence; compared with eGFR of 60\u201074\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    , the adjusted hazard ratios (HRs) (95% confidence intervals [CIs]) for eGFRs of \u226590, 75\u201089, 45\u201059, 30\u201044 and 10\u201029\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    were 1.18 (1.07\u20101.29), 1.09 (1.01\u20101.17), 0.93 (0.83\u20101.04), 1.36 (1.00\u20101.84) and 1.12 (0.55\u20102.26), respectively. High eGFR was associated with higher cancer mortality, while low eGFR was not; the adjusted subdistribution HRs (95% CIs) for eGFRs of \u226590 and 75\u201089\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    were 1.58 (1.29\u20101.94) and 1.27 (1.08\u20101.50), respectively. Subgroup analyses of participants with eGFRs \u226560 and &lt;60\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    revealed elevated cancer risks of smoking and family history of cancer in those with eGFR &lt;60\u2009ml\/min\/1.73\u2009m\n                    <jats:sup>2<\/jats:sup>\n                    , with significant interactions. Our findings suggest that the relationship between eGFR and cancer incidence was U\u2010shaped. Only high eGFR was associated with cancer mortality. Kidney dysfunction enhanced cancer risk from smoking.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34554","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T14:48:52Z","timestamp":1683730132000},"page":"732-741","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Association of kidney function with cancer incidence and its influence on cancer risk of smoking: The Japan Multi\u2010Institutional Collaborative Cohort Study"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-2380","authenticated-orcid":false,"given":"Shimon","family":"Kurasawa","sequence":"first","affiliation":[{"name":"Department of Nephrology Nagoya University Graduate School of Medicine  Nagoya Japan"},{"name":"Department of Clinical Research Education Nagoya University Graduate School of Medicine  Nagoya 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