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A real\u2010world multicenter study was conducted to characterize treatment patterns and outcomes in patients with newly diagnosed MCL by Chinese Hematologist and Oncologist Innovation Cooperation of the Excellent (CHOICE). The final analysis included 1261 patients. Immunochemotherapy was the most common first\u2010line treatment, including R\u2010CHOP in 34%, cytarabine\u2010containing regimens in 21% and BR in 3% of the patients. Eleven percent (n\u2009=\u2009145) of the patients received BTKi\u2010based frontline therapy. Seventeen percent of the patients received maintenance rituximab. Autologous hematopoietic stem cell transplantation (AHCT) was conducted in 12% of the younger (&lt;65\u2009years) patients. In younger patients, propensity score matching analysis did not show significant difference in 2\u2010year progression\u2010free survival and 5\u2010year overall survival rate in patients receiving standard high\u2010dose immunochemotherapy followed by AHCT than induction therapy with BTKi\u2010based regimens without subsequent AHCT (72% vs 70%, <jats:italic>P<\/jats:italic>\u2009=\u2009.476 and 91% vs 84%, <jats:italic>P<\/jats:italic>\u2009=\u2009.255). In older patients, BTKi combined with bendamustine plus rituximab (BR) was associated with the lowest POD24 rate (17%) compared with BR and other BTKi\u2010containing regimens. In patients with resolved hepatitis B at the baseline, HBV reactivation rate was 2.3% vs 5.3% in those receiving anti\u2010HBV prophylaxis vs not; BTKi treatment was not associated with higher risk of HBV reactivation. In conclusion, non\u2010HD\u2010AraC chemotherapy combined with BTKi may be a viable therapeutic strategy for younger patients. Anti\u2010HBV prophylaxis should be implemented in patients with resolved hepatitis B.<\/jats:p>","DOI":"10.1002\/ijc.34565","type":"journal-article","created":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T14:54:41Z","timestamp":1684508081000},"page":"1016-1025","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment patterns and clinical outcomes of mantle cell lymphoma: A retrospective cohort study by CHOICE"],"prefix":"10.1002","volume":"153","author":[{"given":"Dongfeng","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine Sun Yat\u2010sen University Cancer Center  Guangzhou Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Fang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental 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