{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:03:54Z","timestamp":1783479834973,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,29]],"date-time":"2023-05-29T00:00:00Z","timestamp":1685318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C1010786"],"award-info":[{"award-number":["2020R1A2C1010786"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A5A2019210"],"award-info":[{"award-number":["2020R1A5A2019210"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021R1A2C1011958"],"award-info":[{"award-number":["2021R1A2C1011958"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between a family history of breast cancer (FHBC) in female first\u2010degree relatives (FDRs) and cancer risk in men has not been evaluated. This study aimed to compare the risks of overall and site\u2010specific cancers in men with and without FHBC. A population\u2010based study was conducted with 3\u2009329\u2009106 men aged \u226540\u2009years who underwent national cancer screening between 2013 and 2014. Men with and without FHBC in their female FDRs were age\u2010matched in a 1:4 ratio. Men without FHBC were defined as those without a family history of any cancer type in their FDRs. Data from 69\u2009124 men with FHBC and 276\u2009496 men without FHBC were analyzed. The mean follow\u2010up period was 4.7\u2009\u00b1\u20090.9\u2009years. Men with an FHBC in any FDR (mother or sister) had a higher risk of pancreatic, thyroid, prostate and breast cancers than those without an FHBC (adjusted hazard ratios [aHRs] (95% confidence interval [CI]): 1.35 (1.07\u20101.70), 1.33 (1.12\u20101.56), 1.28 (1.13\u20101.44) and 3.03 (1.130\u20108.17), respectively). Although an FHBC in any one of the FDRs was not associated with overall cancer risk, FHBC in both mother and sibling was a significant risk factor for overall cancer (aHR: 1.69, 95% CI:1.11\u20102.57) and increased the risk of thyroid cancer by 3.41\u2010fold (95% CI: 1.10\u201010.61). FHBC in the mother or sister was a significant risk factor for pancreatic, thyroid, prostate and breast cancers in men; therefore, men with FHBC may require more careful <jats:italic>BRCA1\/2<\/jats:italic> mutation\u2010related cancer surveillance.<\/jats:p>","DOI":"10.1002\/ijc.34573","type":"journal-article","created":{"date-parts":[[2023,5,30]],"date-time":"2023-05-30T05:41:31Z","timestamp":1685425291000},"page":"950-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increased risk of pancreatic, thyroid, prostate and breast cancers in men with a family history of breast cancer: A population\u2010based study"],"prefix":"10.1002","volume":"153","author":[{"given":"Huiyeon","family":"Song","sequence":"first","affiliation":[{"name":"Graduate School of Public Health Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Suk","family":"Jung","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thi Xuan Mai","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2550-913X","authenticated-orcid":false,"given":"Chang Mo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, College of Medicine Ewha Womans University  Seoul Republic of Korea"},{"name":"Inflammation\u2010Cancer Microenvironment Research Center, College of Medicine Ewha Womans University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-3184","authenticated-orcid":false,"given":"Boyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Hanyang University College of Medicine  Seoul Republic of Korea"},{"name":"Hanyang Institute of Bioscience and Biotechnology Hanyang University  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2021.02.021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.10.042"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt280"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2018.04.001"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19600-4"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-662"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6055-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.212727"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2017.32.11.1764"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101566"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780195311174.001.0001"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60269-X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23033"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000201)88:3<653::AID-CNCR24>3.0.CO;2-1"},{"key":"e_1_2_11_16_1","article-title":"Validation of Cancer Diagnosis Based on the National Health Insurance Service Database versus the National Cancer Registry Database in Korea","volume":"54","author":"Yang MS","year":"2021","journal-title":"Cancer Res Treat"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2022.128"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603535"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.055"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-021-01675-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-021-06413-2"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4048\/jbc.2013.16.4.357"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24284"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74172-z"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2022.01.016"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1919976117"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01260-3"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-020-0613-6"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03532-4"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2795-c1"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-15-0833"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0877"},{"key":"e_1_2_11_33_1","volume-title":"Epidemiology E\u2010Book","author":"Gordis L","year":"2013"},{"key":"e_1_2_11_34_1","first-page":"1","article-title":"Collection and use of cancer family history in primary care","volume":"159","author":"Qureshi N","year":"2007","journal-title":"Evid Rep Technol Assess (Full Rep)"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605421"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.820643"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34573","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:12:26Z","timestamp":1692292346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34573"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,29]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/ijc.34573"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34573","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,29]]},"assertion":[{"value":"2022-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}