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This article detected distinct invasion patterns of BC cells between the ER\u2010positive and TNBC using intraductal murine models with intraductal administration of carbon nanoparticles (CNPs). First, the feasibility of the utility of CNPs as a tracer was proved. The area ratio of CNPs and tumor cells invading the stroma at the late stage was found significantly higher than that in the early stage in MNU\u2010induced ER\u2010positive BC. However, opposite results were obtained in the triple\u2010negative model. Consequently, we proposed that the ER\u2010positive phenotype cells behave differently between different stages during tumor progression while there is no such difference in the invasion process of TNBC cells. The analysis regarding the duct integrity along with immunohistochemical characteristics further explained the distinct invasion features between the ER\u2010positive and triple\u2010negative subtypes. Last, the relationship between the duct thickness and the duct integrity suggested that ER\u2010positive tumors gradually increased in size within the lumen before the invasion. Overall, this study suggested the different invasion characteristics of ER\u2010positive BC and TNBC in vivo.<\/jats:p>","DOI":"10.1002\/ijc.34611","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T12:12:40Z","timestamp":1685535160000},"page":"1067-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Distinct invasive patterns in situ between estrogen receptor\u2010positive and triple\u2010negative breast cancer through the intraductal tracking of carbon nanoparticles"],"prefix":"10.1002","volume":"153","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6876-7844","authenticated-orcid":false,"given":"Xinwen","family":"Kuang","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan University  Wuhan People's Republic of China"},{"name":"Peking Union Medical College, Chinese Academy of Medical Sciences Peking Union Medical 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