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Using data collected between 2011 and 2021 at Inkosi Albert Luthuli Central Hospital, this retrospective study describes demographic and genetic trends for hereditary breast cancer patients in the KwaZulu\u2010Natal province, South Africa. Six hundred and forty\u2010five patients were included, of whom 44.3% were Black, 36.8% Indian, 15.6% White and 3.2% Coloured. The number of annual new cases increased from eight in 2011 to 145 in 2021, with a notable increase among Blacks. The mean onset age was 46\u2009years, and Black patients were diagnosed ~10\u2009years earlier than White and Indian patients. Triple\u2010negative breast cancers accounted for 20.3% of hereditary cases, and 51.1% of them were Black. Bilateral and recurrent breast cancers constituted 7.4%, while pathogenic sequence variants in <jats:italic>BRCA1\/2<\/jats:italic> were reported in 10.4% of all patients, and the majority were Blacks and Indians. Overall, the KwaZulu\u2010Natal province has seen an increase in hereditary breast cancer incidence in the past decade. Despite testing negative for pathogenic sequence variants, Black women frequently presented with breast cancers that are <jats:italic>BRCA1<\/jats:italic>\u2010like, while Indians presented with extensive family history. This suggests that South African patients may require unique approaches to interventions, such as early detection and awareness programs among Blacks and increased genetic screening among Indians.<\/jats:p>","DOI":"10.1002\/ijc.34687","type":"journal-article","created":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T10:44:37Z","timestamp":1692009877000},"page":"65-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Recent trends in hereditary breast cancer incidence by race and age in KwaZulu\u2010Natal, South Africa: An 11\u2010year single\u2010centre retrospective study (2011\u20102021)"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7156-6699","authenticated-orcid":false,"given":"Mpoi","family":"Makhetha","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Nelson R Mandela School of Medicine College of Health Sciences, University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Namitha","family":"Chabilal","sequence":"additional","affiliation":[{"name":"Department of Genetics Inkosi Albert Luthuli Central Hospital  KwaZulu\u2010Natal South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colleen","family":"Aldous","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Nelson R Mandela School of Medicine College of Health Sciences, University of KwaZulu\u2010Natal  Durban South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_11_4_1","unstructured":"Global Cancer Observatory.Fact sheet: South Africa.2020https:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/710-south-africa-fact-sheets.pdf"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2015.1115118"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2022.102139"},{"issue":"1","key":"e_1_2_11_7_1","first-page":"24","article-title":"BRCA1 expression in triple negative sporadic breast cancers","volume":"32","author":"Galizia E","year":"2010","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1913-6"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34503"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32293"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33846"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2022.04.071"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-017-9985-x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14808"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.50.9984"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S206949"},{"key":"e_1_2_11_17_1","unstructured":"National Cancer Registry.Cancer in South Africa 2001 full report.2001https:\/\/www.nicd.ac.za\/wp-content\/uploads\/2019\/12\/2001-NCR-2001-results.pdf"},{"key":"e_1_2_11_18_1","unstructured":"National Cancer Registry.Cancer in South Africa 2019 full report.2021https:\/\/cansa.org.za\/files\/2022\/03\/NCR_Path_2019_Full_Report_8dec2021.pdf"},{"key":"e_1_2_11_19_1","unstructured":"Statistics South Africa.The 2022 Mid\u2010Year population estimates.2022https:\/\/www.statssa.gov.za\/?p=15601"},{"key":"e_1_2_11_20_1","unstructured":"South African History Online.Race and ethnicity in South Africa. 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