{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T18:45:52Z","timestamp":1785005152930,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T00:00:00Z","timestamp":1692576000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010348","name":"Familien Erichsens Mindefond","doi-asserted-by":"publisher","award":["6000073"],"award-info":[{"award-number":["6000073"]}],"id":[{"id":"10.13039\/501100010348","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["18\u2010B\u20100016"],"award-info":[{"award-number":["18\u2010B\u20100016"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01CA236816\u201001A1"],"award-info":[{"award-number":["1R01CA236816\u201001A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007371","name":"Svend Andersen Fonden","doi-asserted-by":"publisher","award":["81A\u201001"],"award-info":[{"award-number":["81A\u201001"]}],"id":[{"id":"10.13039\/501100007371","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["2009\u201007\u201028"],"award-info":[{"award-number":["2009\u201007\u201028"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["2010\u201011\u201012"],"award-info":[{"award-number":["2010\u201011\u201012"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal smoking in pregnancy may increase the risk of testicular germ cell cancer (TGCC) in offspring, but current evidence remains inconclusive. We performed a nested case\u2010control study using cotinine measurements in maternal serum and amniotic fluid as a biomarker for tobacco exposure during pregnancy. A total of 654 males with maternal serum (n\u2009=\u2009359, n<jats:sub>cases\/controls<\/jats:sub>\u2009=\u200971\/288) and\/or amniotic fluid (n\u2009=\u2009295, n<jats:sub>cases\/controls<\/jats:sub>\u2009=\u200966\/229) samples were included. Data on TGCC diagnoses and relevant covariates were derived from nationwide Danish health registries. Cotinine was quantified by liquid chromatography tandem mass spectrometry. An adapted cox regression model estimated the risk of TGCC considering active and inactive tobacco use defined according to cotinine concentrations of &lt;, \u226515\u2009ng\/ml. Overall, the concentrations of cotinine were comparable in maternal serum and amniotic fluid (median<jats:sub>serum\/amniotic fluid<\/jats:sub>: 2.1\/2.6\u2009ng\/ml). A strong statistically significant correlation was detected in 14 paired samples (Spearman <jats:italic>rho<\/jats:italic>: 0.85). Based on maternal serum cotinine concentrations, exposure to active tobacco use was not associated with risk of TGCC in offspring (HR 0.88, 95% CI 0.51; 1.52). Similarly, based on amniotic fluid cotinine concentrations, exposure to active tobacco use was not associated with risk of TGCC (HR 1.11, 95% CI 0.64; 1.95). However, different risks were observed for seminomas and nonseminomas in both matrices, but none were statistically significant. Our findings did not provide convincing evidence supporting that exposure to tobacco during pregnancy is associated with TGCC.<\/jats:p>","DOI":"10.1002\/ijc.34688","type":"journal-article","created":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T04:18:49Z","timestamp":1692677929000},"page":"71-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cotinine concentrations in maternal serum and amniotic fluid during pregnancy and risk of testicular germ cell cancer in the offspring: A prospective nested case\u2010control study"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3366-9723","authenticated-orcid":false,"given":"Astrid L.","family":"Beck","sequence":"first","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie S.","family":"Uldbjerg","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn\u2010Hee","family":"Lim","sequence":"additional","affiliation":[{"name":"Section of Environmental Health, Department of Public Health University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Preventive Medicine Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent A.","family":"Coull","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, T.H. Chan School of Public Health Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina M.","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Danish National Biobank Statens Serum Institut  K\u00f8benhavn Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena M.","family":"Utko","sequence":"additional","affiliation":[{"name":"Digital Infrastructure Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartlomiej","family":"Wilkowski","sequence":"additional","affiliation":[{"name":"Digital Infrastructure Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panu","family":"Rantakokko","sequence":"additional","affiliation":[{"name":"Department of Health Security Finnish Institute for Health and Welfare  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Lindh","sequence":"additional","affiliation":[{"name":"Division of Occupational and Environmental Medicine, Department of Laboratory Medicine Lund University  Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen H.","family":"Petersen","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"Section of Biostatistics, Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels E.","family":"Skakkeb\u00e6k","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russ","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Environmental Health, T.H. Chan School of Public Health Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Juul","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"},{"name":"Department of Clinical Medicine University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira V.","family":"Br\u00e4uner","sequence":"additional","affiliation":[{"name":"Department of Growth and Reproduction Copenhagen University Hospital\u2014Rigshospitalet  Copenhagen Denmark"},{"name":"International Research and Research Training Centre in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,21]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Testicle cancer","author":"Gaddam SJ","year":"2023"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2022.06.009"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.5.972"},{"key":"e_1_2_13_5_1","volume-title":"Testicular cancer: pathogenesis, diagnosis and management with focus on endocrine aspects","author":"Rajpert\u2010De Meyts E","year":"2000"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.06.028"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.04.058"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869709100734"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/life13030618"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2009.01.017"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810387965"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/1403494810393562"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2015.02.024"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.106716"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2019.1691865"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/biomet\/65.1.153"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010021\u201000778\u2010w"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaa167"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/FTD.0b013e3181957a3b"},{"issue":"9","key":"e_1_2_13_20_1","first-page":"4812","article-title":"Prenatal and perinatal risk factors for testicular cancer","volume":"46","author":"Brown LM","year":"1986","journal-title":"Cancer Res"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:CACO.0000024257.49409.1f"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alcohol.2008.12.002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100215(20000801)87:3<438::aid\u2010ijc20>3.0.co;2\u20101"},{"issue":"7","key":"e_1_2_13_24_1","first-page":"643","article-title":"Maternal lung cancer and testicular cancer risk in the offspring","volume":"12","author":"Kaijser M","year":"2003","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20088"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102605.2005.00599.x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20100215(19960503)66:3<287::AID\u2010IJC2>3.0.CO;2\u2010V"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22523"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055\u20109965.EPI\u201006\u20100389"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.116"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3727\/000000006783980928"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230503"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000254061.90686.9f"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2006.03.042"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.973016"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431\u2010006\u20100304\u2010z"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066766"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/gco.0000000000000283"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182342b7f"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1159\/000457063"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029\u20107844(98)00318\u20104"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1067\/mcp.2000.106129"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01959534"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T06:04:02Z","timestamp":1699855442000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,21]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/ijc.34688"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34688","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,21]]},"assertion":[{"value":"2023-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}