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There are several markers for HPV\u2010driven HNC, one being HPV early antigen serology. We aimed to investigate the diagnostic accuracy of HPV serology and its performance across patient characteristics. Data from the VOYAGER consortium was used, which comprises five studies on HNC from North America and Europe. Diagnostic accuracy, that is, sensitivity, specificity, Cohen's kappa and correctly classified proportions of HPV16 E6 serology, was assessed for OPC and other HNC using p16<jats:sup>INK4a<\/jats:sup> immunohistochemistry (p16), HPV in situ hybridization (ISH) and HPV PCR as reference methods. Stratified analyses were performed for variables including age, sex, smoking and alcohol use, to test the robustness of diagnostic accuracy. A risk\u2010factor analysis based on serology was conducted, comparing HPV\u2010driven to non\u2010HPV\u2010driven OPC. 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Future research is suggested on the influence of smoking on HPV antibody levels.<\/jats:p>","DOI":"10.1002\/ijc.34710","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:23:56Z","timestamp":1694424236000},"page":"389-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Diagnostic accuracy of <scp>HPV16<\/scp> early antigen serology for <scp>HPV<\/scp>\u2010driven oropharyngeal cancer is independent of age and sex"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2509-1661","authenticated-orcid":false,"given":"Johannes M. 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