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This was a Dutch, multicenter cohort study. Eligible patients were \u226518\u2009years, with metastatic <jats:italic>EGFR<\/jats:italic>m<jats:italic>+<\/jats:italic> NSCLC, receiving osimertinib. Primary endpoint was progression\u2010free survival (PFS). Secondary endpoints included overall survival (OS) and safety. Kaplan\u2010Meier analyses and multivariate Cox proportional hazard models were performed. In total, 294 patients were included. Primary <jats:italic>EGFR<\/jats:italic>\u2010mutations were mainly exon 19 deletions (54%) and p.L858R point mutations (30%). Osimertinib was given in first\u2010line (40%), second\u2010line (46%) or beyond (14%), with median PFS 14.4 (95% CI: 9.4\u201019.3), 13.9 (95% CI: 11.3\u201016.1) and 8.7\u2009months (95% CI: 4.6\u201012.7), respectively. Patients with low BMI (&lt;20.0\u2009kg\/m<jats:sup>2<\/jats:sup>) had significantly shorter PFS\/OS compared to all other subgroups. Patients with a high plasma trough concentration in steady state (C<jats:sub>min,SS<\/jats:sub>; &gt;271\u2009ng\/mL) had shorter PFS compared to a low C<jats:sub>min,SS<\/jats:sub> (&lt;163\u2009ng\/mL; aHR 2.29; 95% CI: 1.13\u20104.63). A significant longer PFS was seen in females (aHR\u2009=\u20090.61, 95% CI: 0.45\u20100.82) and patients with the exon 19 deletion (aHR\u2009=\u20090.58, 95% CI: 0.36\u20100.92). A trend towards longer PFS was seen for <jats:italic>TP53<\/jats:italic> wild\u2010type patients, while age did not impact PFS. Patients with a primary <jats:italic>EGFR<\/jats:italic> exon 19 deletion had longer PFS, while a low BMI, male sex and a high C<jats:sub>min,SS<\/jats:sub> were indicative for shorter PFS and\/or OS. Age was not associated with effectiveness outcomes of osimertinib.<\/jats:p>","DOI":"10.1002\/ijc.34742","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:55:32Z","timestamp":1697435732000},"page":"332-342","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Exploring the impact of patient\u2010specific clinical features on osimertinib effectiveness in a real\u2010world cohort of patients with <i>EGFR<\/i> mutated non\u2010small cell lung cancer"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-5791","authenticated-orcid":false,"given":"Ard","family":"van Veelen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy &amp; Toxicology Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"CARIM School for Cardiovascular Disease Maastricht University Medical Center+  Maastricht The Netherlands"},{"name":"Division of Pharmacoepidemiology and Clinical Pharmacology Utrecht Institute for Pharmaceutical Sciences  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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