{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:55:36Z","timestamp":1790654136888,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T00:00:00Z","timestamp":1697328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["Z99 CA999999"],"award-info":[{"award-number":["Z99 CA999999"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["ZIA CP010218"],"award-info":[{"award-number":["ZIA CP010218"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01 CA144034"],"award-info":[{"award-number":["R01 CA144034"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["R01CA 043092"],"award-info":[{"award-number":["R01CA 043092"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007197","name":"U.S. Public Health Service","doi-asserted-by":"publisher","award":["UM1 CA182876"],"award-info":[{"award-number":["UM1 CA182876"]}],"id":[{"id":"10.13039\/100007197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated whether aflatoxin B<jats:sub>1<\/jats:sub> (AFB<jats:sub>1<\/jats:sub>) exposure was associated with later risk of developing gallbladder cancer (GBC). We measured AFB<jats:sub>1<\/jats:sub>\u2010lysine albumin adducts in baseline samples from the Shanghai Cohort Study of 18\u2009244 men aged 45 to 64\u2009years (recruited 1986\u20101989). We included 84 GBC cases with sufficient serum and 168 controls matched on age at sample collection, date of blood draw and residence. We calculated adjusted odds ratios (ORs) and 95% confidence intervals (95% CIs) for detectable vs non\u2010detectable AFB<jats:sub>1<\/jats:sub>\u2010lysine albumin adducts and gallbladder cancer. AFB<jats:sub>1<\/jats:sub>\u2010lysine albumin adducts were detected in 50.0% of GBC cases, and risk of GBC was twice as high in those with detectable vs undetectable levels (OR\u2009=\u20092.0, 95% CI\u2009=\u20091.0\u20103.9). ORs ranged from 1.8 (95% CI\u2009=\u20090.75\u20104.3) for 0.5 to &lt;1.75\u2009pg\/mg vs undetectable adduct levels to 2.2 (95% CI\u2009=\u20090.91\u20105.6) for &gt;3.36\u2009pg\/mg vs undetectable, suggesting a dose\u2010response (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u2009.05). When restricted to cases diagnosed before the median time to diagnosis after blood draw (18.4\u2009years), results were similar (OR\u2009=\u20092.2, 95% CI\u2009=\u20090.80\u20105.8) to those for the entire follow\u2010up duration. The OR was 9.4 (95% CI\u2009=\u20091.7\u201051.1) for individuals with detectable AFB<jats:sub>1<\/jats:sub>\u2010lysine albumin adducts and self\u2010reported gallstones compared to individuals with neither. Participants with detectable AFB<jats:sub>1<\/jats:sub>\u2010lysine albumin adducts at baseline had increased risk of developing GBC, replicating the previously observed association between AFB<jats:sub>1<\/jats:sub> exposure and providing the first evidence of temporality.<\/jats:p>","DOI":"10.1002\/ijc.34755","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T06:05:27Z","timestamp":1697436327000},"page":"801-806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Association of aflatoxin with gallbladder cancer in a case\u2010control study nested within a Chinese cohort"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3832-6204","authenticated-orcid":false,"given":"Jill","family":"Koshiol","sequence":"first","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, UPMC Hillman Cancer Center University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Hildesheim","sequence":"additional","affiliation":[{"name":"Division of Cancer Epidemiology and Genetics National Cancer Institute  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Tang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Shanghai Cancer Institute  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Egner","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4620-3108","authenticated-orcid":false,"given":"Jian\u2010Min","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, UPMC Hillman Cancer Center University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Groopman","sequence":"additional","affiliation":[{"name":"Department of Environmental Health and Engineering Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,15]]},"reference":[{"key":"e_1_2_11_2_1","first-page":"99","article-title":"Gallbladder cancer: epidemiology and outcome","volume":"6","author":"Hundal R","year":"2014","journal-title":"Clin Epidemiol"},{"key":"e_1_2_11_3_1","first-page":"661","volume-title":"Cancer Epidemiology and Prevention","author":"Koshiol J","year":"2017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1429"},{"key":"e_1_2_11_5_1","first-page":"225","volume-title":"Aflatoxins A Review of Human Carcinogens. 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