{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T14:05:31Z","timestamp":1772719531015,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Some patients with marginal zone lymphoma (MZL) experience histological transformation to diffuse large B\u2010cell lymphoma (DLBCL). Because of the paucity of long\u2010term data on transformation, we conducted a population\u2010based study to estimate the risk of transformation and its impact on survival in MZL. Using the Surveillance, Epidemiology and End Results database, we identified 23\u2009221 patients with histology\u2010proven MZL between 2000 and 2018. Competing risk method, Kaplan\u2010Meier and Cox proportional hazards regression were performed to analyze time\u2010to\u2010event outcomes. Based on 420 events of transformation, the 10\u2010year cumulative incidence rate of transformation is 2.23% (95% CI: 2.00%\u20102.46%) in MZL, 1.5% (95% CI: 1.3%\u20101.8%), 2.7% (95% CI: 2.3%\u20103.2%) and 5.8% (95% CI: 4.6%\u20107.1%) in extranodal, nodal and splenic MZL (EMZL, NMZL and SMZL), respectively. Patients with SMZL (subdistribution hazard ratio [SHR], 2.96; 95% CI: 2.21\u20103.96) or NMZL (SHR, 1.49; 95% CI: 1.17\u20101.90) have a higher risk of transformation than those with EMZL. For each MZL subtype, patients with transformation had a significantly shorter overall survival. Patients with transformation &gt;18\u2009months since MZL diagnosis had longer OS than those who presented within 18\u2009months (5\u2010year rate, 87.4% [95% CI: 83.7%\u201091.2%] vs 47.9% [95% CI: 38.8%\u201059.0%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Compared to patients with matched de novo DLBCL, those whose DLBCL was transformed from MZL had a shorter OS (5\u2010year rate, 56.6% [95% CI: 51.9%\u201061.8%] vs 46.1% [95% CI: 40.9%\u201051.9%]; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). We concluded that patients with SMZL had the highest risk of transformation. Regardless of MZL subtype, transformation resulted in significantly increased mortality.<\/jats:p>","DOI":"10.1002\/ijc.34773","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T12:43:28Z","timestamp":1698151408000},"page":"969-978","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Transformation to diffuse large B\u2010cell lymphoma and its impact on survival in patients with marginal zone lymphoma: A population\u2010based study"],"prefix":"10.1002","volume":"154","author":[{"given":"Yu","family":"Du","sequence":"first","affiliation":[{"name":"Department of Radiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinlu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaona","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kefeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9421-6344","authenticated-orcid":false,"given":"Min","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-2893","authenticated-orcid":false,"given":"Shugang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Hematology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"WHO Classification of Tumours of Hematopoietic and Lymphoid Tissues (4th Ed)","author":"Swerdlow SH","year":"2017"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/aol-20-28"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.07.002"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.307"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-05-714584"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.6.1950"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-006-0014-9"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt507"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2016.08.029"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V110.11.790.790"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.7577"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2102568"},{"key":"e_1_2_11_14_1","article-title":"Risk factors for transformation to higher\u2010grade lymphoma and its impact on survival in a large cohort of patients with marginal zone lymphoma from a single institution","volume":"12","author":"Alderuccio JP","year":"2018","journal-title":"J Clin Oncol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv368"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1999.10474144"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00831-9"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25226"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14153"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17815"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13320"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07301.x"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2021.06.013"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-04-516815"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21330"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.05.6150"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-04-1279"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.07.5671"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T04:41:02Z","timestamp":1709872862000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,24]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3,15]]}},"alternative-id":["10.1002\/ijc.34773"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34773","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,24]]},"assertion":[{"value":"2023-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}