{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:48:57Z","timestamp":1790898537550,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T00:00:00Z","timestamp":1698624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100011541","name":"Division of Cancer Epidemiology and Genetics, National Cancer Institute","doi-asserted-by":"publisher","award":["ZIA CP010125\u201028"],"award-info":[{"award-number":["ZIA CP010125\u201028"]}],"id":[{"id":"10.13039\/100011541","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human exposure to per\u2010 and polyfluoroalkyl substances (PFAS) occurs globally through contaminated food, dust, and drinking water. Studies of PFAS and thyroid cancer have been limited. We conducted a nested case\u2010control study of prediagnostic serum levels of 19 PFAS and papillary thyroid cancer (400 cases, 400 controls) in the Finnish Maternity Cohort (pregnancies 1986\u20102010; follow\u2010up through 2016), individually matched on sample year and age. We used conditional logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for log\n                    <jats:sub>2<\/jats:sub>\n                    transformed and categorical exposures, overall and stratified by calendar period, birth cohort, and median age at diagnosis. We adjusted for other PFAS with Spearman correlation rho\u2009=\u20090.3\u20100.6. Seven PFAS, including perfluoroctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), N\u2010ethyl\u2010perfluorooctane sulfonamidoacetic acid (EtFOSAA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorohexane sulfonic acid (PFHxS) were detected in &gt;50% of women. These PFAS were not associated with risk of thyroid cancer, except for PFHxS, which was inversely associated (OR log\n                    <jats:sub>2<\/jats:sub>\n                    \u2009=\u20090.82, 95% CI: 0.70\u20100.97). We observed suggestive but imprecise increased risks associated with PFOA, PFOS, and EtFOSAA for those diagnosed at ages &lt;40\u2009years, whereas associations were null or inverse among those diagnosed at 40+ years (\n                    <jats:italic>P<\/jats:italic>\n                    \u2010interaction: .02, .08, .13, respectively). There was little evidence of other interactions. These results show no clear association between PFAS and papillary thyroid cancer risk. Future work would benefit from evaluation of these relationships among those with higher exposure levels and during periods of early development when the thyroid gland may be more susceptible to environmental harms.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34776","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:40:14Z","timestamp":1698655214000},"page":"979-991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prediagnostic serum concentrations of per\u2010 and polyfluoroalkyl substances and risk of papillary thyroid cancer in the Finnish Maternity Cohort"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-5109","authenticated-orcid":false,"given":"Jessica M.","family":"Madrigal","sequence":"first","affiliation":[{"name":"Occupational &amp; Environmental Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics (DCEG) National Cancer Institute (NCI)  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Troisi","sequence":"additional","affiliation":[{"name":"Trans\u2010Divisional Research Program DCEG, NCI  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helj\u00e4\u2010Marja","family":"Surcel","sequence":"additional","affiliation":[{"name":"Biobank Borealis of Northern Finland Oulu University Hospital  Oulu Finland"},{"name":"Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna","family":"\u00d6hman","sequence":"additional","affiliation":[{"name":"Biobank Borealis of Northern Finland Oulu University Hospital  Oulu Finland"},{"name":"Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Kivel\u00e4","sequence":"additional","affiliation":[{"name":"Biobank Borealis of Northern Finland Oulu University Hospital  Oulu Finland"},{"name":"Faculty of Medicine University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Kiviranta","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare\/Environmental Health Unit  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panu","family":"Rantakokko","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare\/Environmental Health Unit  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jani","family":"Koponen","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare\/Environmental Health Unit  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-5750","authenticated-orcid":false,"given":"Danielle N.","family":"Medgyesi","sequence":"additional","affiliation":[{"name":"Occupational &amp; Environmental Epidemiology Branch, Division of Cancer Epidemiology &amp; Genetics (DCEG) National Cancer Institute (NCI)  Rockville Maryland USA"},{"name":"Department of Environmental Health Sciences, Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-4432","authenticated-orcid":false,"given":"Cari M.","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Radiation Epidemiology Branch DCEG, NCI  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2329-9933","authenticated-orcid":false,"given":"Katherine A.","family":"McGlynn","sequence":"additional","affiliation":[{"name":"Metabolic Epidemiology Branch DCEG, NCI  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Sampson","sequence":"additional","affiliation":[{"name":"Biostatistics Branch DCEG, NCI  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul S.","family":"Albert","sequence":"additional","affiliation":[{"name":"Biostatistics Branch DCEG, NCI  Rockville Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary H.","family":"Ward","sequence":"additional","affiliation":[{"name":"Occupational &amp; 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