{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:26:32Z","timestamp":1792009592679,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T00:00:00Z","timestamp":1699056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney transplant (KT) recipients are known to be at risk of developing several cancer types; however, cancer mortality in this population is underinvestigated. Our study aimed to assess the risk of cancer death among Italian KT recipients compared to the corresponding general population. A cohort study was conducted among 7373 individuals who underwent KT between 2003 and 2020 in 17 Italian centers. Date and cause of death were retrieved until 31 December 2020. Indirect standardization was used to estimate standardized mortality ratios (SMRs) and corresponding 95% confidence intervals (CIs). Cancer was the most common cause of death among the 7373 KT recipients, constituting 32.4% of all deaths. A 1.8\u2010fold excess mortality (95% CI: 1.59\u20102.09) was observed for all cancers combined. Lymphomas (SMR\u2009=\u20096.17, 95% CI: 3.81\u20109.25), kidney cancer (SMR\u2009=\u20095.44, 95% CI: 2.97\u20108.88) and skin melanoma (SMR\u2009=\u20093.19, 95% CI: 1.03\u20106.98) showed the highest excess death risks. In addition, SMRs were increased about 1.6 to 3.0 times for cancers of lung, breast, bladder and other hematopoietic and lymphoid tissues. As compared to the general population, relative cancer mortality risk remained significantly elevated in all age groups though it decreased with increasing age. A linear temporal increase in SMR over time was documented for all cancers combined (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Our study documented significantly higher risks of cancer death in KT recipients than in the corresponding general population. Such results support further investigation into the prevention and early detection of cancer in KT recipients.<\/jats:p>","DOI":"10.1002\/ijc.34787","type":"journal-article","created":{"date-parts":[[2023,11,4]],"date-time":"2023-11-04T11:34:19Z","timestamp":1699097659000},"page":"842-851","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cancer mortality after kidney transplantation: A multicenter cohort study in Italy"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6731-7569","authenticated-orcid":false,"given":"Martina","family":"Taborelli","sequence":"first","affiliation":[{"name":"Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano (CRO), IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0565-8920","authenticated-orcid":false,"given":"Diego","family":"Serraino","sequence":"additional","affiliation":[{"name":"Unit of Cancer Epidemiology Centro di Riferimento Oncologico di Aviano (CRO), IRCCS  Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Cimaglia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Pre\u2010Clinical Research National Institute for Infectious Diseases \u201cL. Spallanzani\u201d IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucrezia","family":"Furian","sequence":"additional","affiliation":[{"name":"Unit of Kidney and Pancreas Transplantation, Department of Surgical, Oncological and Gastroenterological Sciences University of Padova  Padova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Biancone","sequence":"additional","affiliation":[{"name":"Division of Nephrology Dialysis and Transplantation Renal Transplantation Center \u201cA. 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Gemelli IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimiliano","family":"Veroux","sequence":"additional","affiliation":[{"name":"Organ Transplantation Unit, Department of Medical and Surgical Sciences and Advanced Technologies University Hospital of Catania  Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Iaria","sequence":"additional","affiliation":[{"name":"Department of General and Specialized Surgery, Division of General Surgery, Transplant Surgery Unit Parma University Hospital  Parma Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Argiolas","sequence":"additional","affiliation":[{"name":"Renal Transplant Unit Azienda Ospedaliera Brotzu  Cagliari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Todeschini","sequence":"additional","affiliation":[{"name":"Department of Experimental Diagnostic and Specialty Medicine (DIMEC), Nephrology, Dialysis and Renal Transplant Unit, IRCCS S. 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