{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T03:21:20Z","timestamp":1768792880574,"version":"3.49.0"},"reference-count":50,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001006","name":"Breast Cancer Research Foundation","doi-asserted-by":"publisher","award":["BCRF\u201023\u2010140"],"award-info":[{"award-number":["BCRF\u201023\u2010140"]}],"id":[{"id":"10.13039\/100001006","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Observational studies have shown associations between circulating levels of various biomarkers (eg, total cholesterol [TC], low\u2010density lipoprotein cholesterol [LDL], insulin\u2010like growth factor\u20101 [IGF\u20101], C\u2010reactive protein [CRP] and glycated hemoglobin\u20101c [HbA1c]) and the risk of invasive breast cancer (IBC). Ductal carcinoma in situ of the breast (DCIS) is a nonobligate precursor of IBC and shares several risk factors with it. However, the relationship between these biomarkers and DCIS risk remains unexplored. We studied the association between circulating levels of TC, LDL\u2010C, high\u2010density lipoprotein cholesterol (HDL\u2010C), Lipoprotein (a) (Lp\u2010(a)), IGF\u20101, CRP and HbA1c, with the risk of DCIS in 156801women aged 40 to 69\u2009years and breast cancer\u2010free at enrolment when blood samples and information on demographic and health\u2010related factors were collected. Incident cases of DCIS were ascertained during the follow\u2010up via linkage to the UK cancer registries Multivariable\u2010adjusted Cox proportional hazards models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of interest. In all, 969 DCIS incident cases were diagnosed during 11.4\u2009years of follow\u2010up. Total cholesterol was inversely associated with the risk of DCIS (HR<jats:sub>quintile(Q)5vsQ1<\/jats:sub>\u2009=\u20090.47, 95% CI: 0.27\u20100.82, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u2009<jats:italic>.008<\/jats:italic>). Conversely, LDL\u2010C was positively associated with DCIS risk (HR<jats:sub>Q3vsQ1<\/jats:sub>\u2009=\u20091.43, 95% CI: 1.01\u20102.04, HR<jats:sub>Q4vsQ1<\/jats:sub>\u2009=\u20091.60, 95% CI: 1.04\u20102.47, HR<jats:sub>Q5vsQ1<\/jats:sub>\u2009=\u20092.29, 95% CI: 1.36\u20103.88, <jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub>\u2009=\u2009<jats:italic>.004<\/jats:italic>). In postmenopausal women, CRP had a weak positive association with DCIS risk, while HbA1c showed a nonlinear association with the risk. These results, in conjunction with those from previous studies on IBC, provide support for the association of several biomarkers with the risk of an early stage of breast cancer.<\/jats:p>","DOI":"10.1002\/ijc.34795","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T06:18:58Z","timestamp":1701152338000},"page":"1191-1203","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Circulating levels of biomarkers and risk of ductal carcinoma in situ of the breast in the <scp>UK<\/scp> Biobank study"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1784-7921","authenticated-orcid":false,"given":"Rita","family":"Peila","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Rohan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Population Health Albert Einstein College of Medicine  Bronx New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.211839"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-020-01287-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canep.2019.101648"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30411-4"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djq526"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2339-3"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu5041218"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.02.017"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.187"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000053211"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2012.113"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3490559"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0594-8"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4549676"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22336"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2020.110748"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S000711451500183X"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym276"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.gme.0000198485.70703.7a"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-19-1623"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.01.066"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp425"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-019-1124-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14235043"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2014.10.001"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-014-9884-5"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.31.5200"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-012-2131-4"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142669"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0b013e31828ce95d"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06467-9"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000507554"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm_00000084"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2835"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.11.033"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003302"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2007.02.006"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-022-00784-y"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27394"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038784"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdm135"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-3922"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22717"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005950916707"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70095-4"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-1281"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02660-2"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2011.599831"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02506-x"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.34795","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T07:21:50Z","timestamp":1716535310000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.34795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,27]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["10.1002\/ijc.34795"],"URL":"https:\/\/doi.org\/10.1002\/ijc.34795","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,27]]},"assertion":[{"value":"2023-07-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}