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Epigenetic irregularities in T\u2010ALL include alterations in both DNA methylation and the post\u2010translational modifications on histones which together play a critical role in the initiation and development of T\u2010ALL. Characterizing the oncogenic mutations that result in these epigenetic changes combined with the reversibility of epigenetic modifications represents an opportunity for the development of epigenetic therapies. Oncogenic mutations and deregulated expression of DNA methyltransferases (\n                    <jats:italic>DNMTs<\/jats:italic>\n                    ), Ten\u2010Eleven Translocation dioxygenases (\n                    <jats:italic>TETs<\/jats:italic>\n                    ), Histone acetyltransferases (\n                    <jats:italic>HATs<\/jats:italic>\n                    ) and members of Polycomb Repressor Complex 2 (\n                    <jats:italic>PRC2<\/jats:italic>\n                    ) have all been identified in T\u2010ALL. This review focuses on the current understanding of how these mutations lead to epigenetic changes in T\u2010ALL, their association with disease pathogenesis and the current efforts to exploit these clinically through the development of epigenetic therapies in T\u2010ALL treatment.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34819","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:29:21Z","timestamp":1703809761000},"page":"1522-1536","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The landscape of alterations affecting epigenetic regulators in T\u2010cell acute lymphoblastic leukemia: Roles in leukemogenesis and therapeutic opportunities"],"prefix":"10.1002","volume":"154","author":[{"given":"Yashna","family":"Walia","sequence":"first","affiliation":[{"name":"Children's Cancer Institute, Lowy Cancer Research Centre, UNSW Sydney  Kensington New South Wales 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