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However, it remains unclear whether resistin is associated with increased mortality after CRC diagnosis. We examined pre\u2010diagnostic serum resistin concentrations in relation to CRC\u2010specific and all\u2010cause mortality among 1343 incident CRC cases from the European Prospective Investigation into Cancer and Nutrition cohort. For CRC\u2010specific mortality as the primary outcome, hazard ratios (HRs) and 95% confidence intervals (95% CI) were estimated from competing risk analyses based on cause\u2010specific Cox proportional hazards models and further in sensitivity analyses using Fine\u2013Gray proportional subdistribution hazards models. For all\u2010cause mortality as the secondary outcome, Cox proportional hazards models were used. Subgroup analyses were performed by sex, tumor subsite, tumor stage, body mass index and time to CRC diagnosis. Resistin was measured on a median of 4.8\u2009years before CRC diagnosis. During a median follow\u2010up of 8.2\u2009years, 474 deaths from CRC and 147 deaths from other causes were observed. Resistin concentrations were not associated with CRC\u2010specific mortality (HR\n                    <jats:sub>Q4vsQ1<\/jats:sub>\n                    \u2009=\u20090.95, 95% CI: 0.73\u20131.23;\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>trend<\/jats:sub>\n                    \u2009=\u2009.97; and HR\n                    <jats:sub>per doubling of resistin concentration<\/jats:sub>\n                    \u2009=\u20091.00; 95% CI: 0.84\u20131.19;\n                    <jats:italic>P<\/jats:italic>\n                    \u2009=\u2009.98) or all\u2010cause mortality. Results from competing risk (sensitivity) analysis were similar. No associations were found in any subgroup analyses. These findings suggest no association between pre\u2010diagnostic circulating resistin concentrations and CRC\u2010specific or all\u2010cause mortality among persons with CRC, and the potential insignificance of resistin in CRC progression.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34830","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:28:45Z","timestamp":1704932925000},"page":"1596-1606","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Pre\u2010diagnostic circulating resistin concentrations and mortality among individuals with colorectal cancer: Results from the European Prospective Investigation into Cancer and Nutrition study"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2129-0911","authenticated-orcid":false,"given":"Thu Thi","family":"Pham","sequence":"first","affiliation":[{"name":"Molecular Epidemiology Research Group Max\u2010Delbrueck\u2010Center for Molecular Medicine in the Helmholtz Association (MDC)  Berlin Germany"},{"name":"Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Corporate Member of Freie Universit\u00e4t Berlin and Hum\u2010boldt\u2010Universit\u00e4t zu Berlin  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7877-205X","authenticated-orcid":false,"given":"Katharina","family":"Nimptsch","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Research Group Max\u2010Delbrueck\u2010Center for Molecular Medicine in the Helmholtz Association (MDC)  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krasimira","family":"Aleksandrova","sequence":"additional","affiliation":[{"name":"Department of Epidemiological Methods and Etiological Research Leibniz Institute for Prevention Research and Epidemiology\u2014BIPS  Bremen Germany"},{"name":"Faculty of Human and Health Sciences University of Bremen  Bremen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazda","family":"Jenab","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolism Branch International Agency for Research on Cancer (IARC\u2010WHO), World Health Organization  Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7805-9913","authenticated-orcid":false,"given":"Veronika","family":"Fedirko","sequence":"additional","affiliation":[{"name":"Department of Epidemiology University of Texas M.D. Anderson Cancer Center  Houston Texas USA"},{"name":"Department of Epidemiology, Rollins School of Public Health Emory University  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kana","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Nutrition Harvard T.H. Chan School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Kirstine","family":"Eriksen","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Tj\u00f8nneland","sequence":"additional","affiliation":[{"name":"Danish Cancer Society Research Center  Copenhagen Denmark"},{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7157-419X","authenticated-orcid":false,"given":"Gianluca","family":"Severi","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris\u2010Saclay UVSQ, Inserm \u201cExposome and Heredity\u201d Team  Villejuif 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