{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:47:46Z","timestamp":1791726466636,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004897","name":"European Organisation for Research and Treatment of Cancer","doi-asserted-by":"publisher","award":["EORTC\u20101629"],"award-info":[{"award-number":["EORTC\u20101629"]}],"id":[{"id":"10.13039\/501100004897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,5,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Head and neck cancer (HNC) patients suffer from a range of health\u2010related quality of life (HRQoL) issues, but little is known about their long\u2010term HRQoL. This study explored associations between treatment group and HRQoL at least 5\u2009years' post\u2010diagnosis in HNC survivors. In an international cross\u2010sectional study, HNC survivors completed the European Organization for Research and Treatment of Cancer (EORTC) quality of life core questionnaire (EORTC\u2010QLQ\u2010C30) and its HNC module (EORTC\u2010QLQ\u2010H&amp;N35). Meaningful HRQoL differences were examined between five treatment groups: (a) surgery, (b) radiotherapy, (c) chemo\u2010radiotherapy, (d) radiotherapy \u00b1 chemotherapy and neck dissection and (e) any other surgery (meaning any tumour surgery that is not a neck dissection) and radiotherapy \u00b1 chemotherapy. Twenty\u2010six sites in 11 countries enrolled 1105 survivors. They had a median time since diagnosis of 8\u2009years, a mean age of 66\u2009years and 71% were male. After adjusting for age, sex, tumour site and UICC stage, there was evidence for meaningful differences (10 points or more) in HRQoL between treatment groups in seven domains (\n                    <jats:italic>Fatigue<\/jats:italic>\n                    ,\n                    <jats:italic>Mouth Pain<\/jats:italic>\n                    ,\n                    <jats:italic>Swallowing<\/jats:italic>\n                    ,\n                    <jats:italic>Senses<\/jats:italic>\n                    ,\n                    <jats:italic>Opening Mouth<\/jats:italic>\n                    ,\n                    <jats:italic>Dry Mouth<\/jats:italic>\n                    and\n                    <jats:italic>Sticky Saliva<\/jats:italic>\n                    ). Survivors who had single\u2010modality treatment had better or equal HRQoL in every domain compared to survivors with multimodal treatment, with the largest differences for\n                    <jats:italic>Dry Mouth<\/jats:italic>\n                    and\n                    <jats:italic>Sticky Saliva<\/jats:italic>\n                    . For\n                    <jats:italic>Global Quality of Life<\/jats:italic>\n                    ,\n                    <jats:italic>Physical and Social Functioning<\/jats:italic>\n                    ,\n                    <jats:italic>Constipation<\/jats:italic>\n                    ,\n                    <jats:italic>Dyspnoea and Financial Difficulties<\/jats:italic>\n                    , at least some treatment groups had better outcomes compared to a general population. Our data suggest that multimodal treatment is associated with worse HRQoL in the long\u2010term compared to single modality.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34861","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:27:59Z","timestamp":1707276479000},"page":"1772-1785","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Long\u2010term health\u2010related quality of life in head and neck cancer survivors: A large multinational study"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0768-5789","authenticated-orcid":false,"given":"Katherine J.","family":"Taylor","sequence":"first","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology, and Informatics University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie D.","family":"Amdal","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital Oslo Norway"},{"name":"Research Support Service Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Bjordal","sequence":"additional","affiliation":[{"name":"Research Support Service Oslo University Hospital Oslo Norway"},{"name":"Faculty of Medicine University of Oslo Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guro L.","family":"Astrup","sequence":"additional","affiliation":[{"name":"Department of Oncology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bente B.","family":"Herlofson","sequence":"additional","affiliation":[{"name":"University of Oslo Faculty of Dentistry Oslo Norway"},{"name":"Department of Otorhinolaryngology Oslo University Hospital Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9deric","family":"Duprez","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy\u2010Oncology Ghent University Hospital, Faculty of Medicine and Health Sciences\u2014Human Structure and Repair, Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo R.","family":"Gama","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery Barretos Cancer Hospital Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Jacinto","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Barretos Cancer Hospital Barretos Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Hammerlid","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Scricciolo","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Ospedale dell'Angelo Venice Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Femke","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC, Location Vrije Universiteit Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irma M.","family":"Verdonck\u2010de Leeuw","sequence":"additional","affiliation":[{"name":"Department Otolaryngology\u2010Head and Neck Surgery Amsterdam UMC, Location Vrije Universiteit Amsterdam The Netherlands"},{"name":"Cancer Center Amsterdam, Treatment and Quality of Life Amsterdam The Netherlands"},{"name":"Department of Clinical, Neuro and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Fanetti","sequence":"additional","affiliation":[{"name":"Division of Radiation Oncology Centro di Riferimento Oncologico di Aviano (CRO) IRCCS Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Guntinas\u2010Lichius","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital Jena Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Inhestern","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Jena University Hospital Jena Germany"},{"name":"Department of Otorhinolaryngology Oberhavelkliniken Hennigsdorf Hennigsdorf Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Dragan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Head and Neck Unit Institut Jules Bordet, Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Fabian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University Hospital Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Boehm","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology St. Georg Hospital Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"W\u00f6hner","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology St. Georg Hospital Leipzig 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Chiara\u201d Hospital, Azienda Provinciale Per I Servizi Sanitari (APSS) Trento Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Plath","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Head and Neck Surgery University Hospital Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Paderno","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery ASST Spedali Civili of Brescia, University of Brescia Brescia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Stempler","sequence":"additional","affiliation":[{"name":"Oral Medicine Unit, Sheba Medical Center Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kouri","sequence":"additional","affiliation":[{"name":"Dental Oncology Unit, Department of Oral Medicine and Pathology and Hospital Dentistry Dental School, National and Kapodistrian University of Athens Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Gr\u00e9goire","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Centre Leon Berard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5784-7964","authenticated-orcid":false,"given":"Susanne","family":"Singer","sequence":"additional","affiliation":[{"name":"Institute of Medical Biostatistics, Epidemiology, and Informatics University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the EORTC Quality of Life Group and the EORTC Head and Neck Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(00)00186-6"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23387"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2017.05.012"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33588"},{"key":"e_1_2_12_6_1","first-page":"12","article-title":"Gender disparities in epidemiology, treatment, and outcome for head and neck cancer in Germany: a population\u2010based long\u2010term analysis from 1996 to 2016 of the Thuringian Cancer Registry","author":"Dittberner A","year":"2020","journal-title":"Cancer"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2014.03.008"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599818792205"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23033"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz084"},{"key":"e_1_2_12_11_1","first-page":"616","article-title":"The new face of head and neck cancer: the HPV epidemic","volume":"29","author":"Lewis A","year":"2015","journal-title":"Oncology (Williston Park)"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.011"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.25095"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-016-2295-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-019-05695-z"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-015-0824-4"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/lio2.702"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00066-020-01737-2"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3599"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000161354.28073.bc"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2011.11.045"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000181507.69620.14"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20334"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)00292-X"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.20735"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2015.05.003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(94)90104-X"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.12.005"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-856"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2016.09.006"},{"key":"e_1_2_12_31_1","unstructured":"Development ES.CHES [Internet]. 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