{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T16:12:32Z","timestamp":1782835952407,"version":"3.54.5"},"reference-count":53,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["7011460"],"award-info":[{"award-number":["7011460"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001160","name":"Health Effects Institute","doi-asserted-by":"publisher","award":["R\u201082811201"],"award-info":[{"award-number":["R\u201082811201"]}],"id":[{"id":"10.13039\/100001160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Air pollution has been shown to significantly impact human health including cancer. Gastric and upper aerodigestive tract (UADT) cancers are common and increased risk has been associated with smoking and occupational exposures. However, the association with air pollution remains unclear. We pooled European subcohorts (N\u2009=\u2009287,576 participants for gastric and N\u2009=\u2009297,406 for UADT analyses) and investigated the association between residential exposure to fine particles (PM<jats:sub>2.5<\/jats:sub>), nitrogen dioxide (NO<jats:sub>2<\/jats:sub>), black carbon (BC) and ozone in the warm season (O<jats:sub>3w<\/jats:sub>) with gastric and UADT cancer. We applied Cox proportional hazards models adjusting for potential confounders at the individual and area\u2010level. During 5,305,133 and 5,434,843 person\u2010years, 872 gastric and 1139 UADT incident cancer cases were observed, respectively. For gastric cancer, we found no association with PM<jats:sub>2.5<\/jats:sub>, NO<jats:sub>2<\/jats:sub> and BC while for UADT the hazard ratios (95% confidence interval) were 1.15 (95% CI: 1.00\u20131.33) per 5\u2009\u03bcg\/m<jats:sup>3<\/jats:sup> increase in PM<jats:sub>2.5<\/jats:sub>, 1.19 (1.08\u20131.30) per 10\u2009\u03bcg\/m<jats:sup>3<\/jats:sup> increase in NO<jats:sub>2<\/jats:sub>, 1.14 (1.04\u20131.26) per 0.5\u2009\u00d7\u200910<jats:sup>\u22125<\/jats:sup>\u2009m<jats:sup>\u22121<\/jats:sup> increase in BC and 0.81 (0.72\u20130.92) per 10\u2009\u03bcg\/m<jats:sup>3<\/jats:sup> increase in O<jats:sub>3w<\/jats:sub>. We found no association between long\u2010term ambient air pollution exposure and incidence of gastric cancer, while for long\u2010term exposure to PM<jats:sub>2.5<\/jats:sub>, NO<jats:sub>2<\/jats:sub> and BC increased incidence of UADT cancer was observed.<\/jats:p>","DOI":"10.1002\/ijc.34864","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T08:14:40Z","timestamp":1707552880000},"page":"1900-1910","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term exposure to air pollution and incidence of gastric and the upper aerodigestive tract cancers in a pooled European cohort: The <scp>ELAPSE<\/scp> project"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-8535","authenticated-orcid":false,"given":"Gabriele","family":"Nagel","sequence":"first","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences Utrecht University  Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Jaensch","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lea","family":"Skodda","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry Ulm University  Ulm Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Rodopoulou","sequence":"additional","affiliation":[{"name":"Department of Hygiene, Epidemiology and Medical Statistics, Medical School National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Strak","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences Utrecht University  Utrecht The Netherlands"},{"name":"National Institute for Public Health and the Environment  Bilthoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees","family":"de Hoogh","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute  Basel Switzerland"},{"name":"University of Basel  Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zorana J.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Bellander","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine, Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Environmental Science Aarhus University  Roskilde Denmark"},{"name":"iClimate \u2013 Interdisciplinary Centre for Climate Change Aarhus University  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fecht","sequence":"additional","affiliation":[{"name":"MRC Centre for Environment and Health, School of Public Health Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Forastiere","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Lazio Region Health Service\/ASL Roma 1  Rome Italy"},{"name":"Environmental Research Group, School of Public Health, Faculty of Medicine Imperial College  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Gulliver","sequence":"additional","affiliation":[{"name":"MRC Centre for Environment and Health, School of Public Health Imperial College London  London UK"},{"name":"Centre for Environmental Health and Sustainability &amp; 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