{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:45:14Z","timestamp":1783529114534,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T00:00:00Z","timestamp":1707868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960571"],"award-info":[{"award-number":["81960571"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960468"],"award-info":[{"award-number":["81960468"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bilateral diffuse metastatic lung adenocarcinoma (BLDM\u2010LUAD) is a special imaging pattern of lung adenocarcinoma (LUAD). We retrospectively assessed survival outcomes and co\u2010mutation characteristics of BLDM\u2010LUAD patients harboring epidermal growth factor receptor (<jats:italic>EGFR<\/jats:italic>) mutations who were treated with <jats:italic>EGFR<\/jats:italic>\u2010yrosine kinase inhibitors (TKIs). From May 2016 to May 2021, among 458 patients who submitted samples for next generation sequencing (NGS) detection in 1125 patients with non\u2010small\u2010cell lung cancer (NSCLC), and 44 patients were diagnosed as BLDM\u2010LUAD. In order to analyze the survival outcomes of BLDM\u2010LUAD patients harboring <jats:italic>EGFR<\/jats:italic> mutations who were treated with <jats:italic>EGFR<\/jats:italic>\u2010TKIs, the factors age, gender, smoking history, hydrothorax, site of <jats:italic>EGFR<\/jats:italic> mutations and <jats:italic>EGFR<\/jats:italic>\u2010TKIs treatment were adjusted using propensity score\u2010matching (PSM). The Kaplan\u2010Meier survival curves and log\u2010rank test were used to analyze progression\u2010free survival (PFS) and overall survival (OS). The co\u2010mutation characteristics of BLDM\u2010LUAD patients harboring <jats:italic>EGFR<\/jats:italic> mutations were analyzed by NGS panels. 64 patients with advanced lung adenocarcinoma harboring <jats:italic>EGFR<\/jats:italic> mutations and first\u2010line treatment of <jats:italic>EGFR<\/jats:italic>\u2010TKIs were successfully matched. BLDM\u2010LUAD (n\u2009=\u200932) have significantly longer median PFS than control group (n\u2009=\u200932) (mPFS: 14 vs 6.2\u2009months; <jats:italic>p<\/jats:italic>\u2009=\u2009.002) and insignificantly longer median OS than control group (mOS: 45 vs 25\u2009months; <jats:italic>p<\/jats:italic>\u2009=\u2009.052). The patients with BLDM\u2010LUAD have the higher frequency of <jats:italic>EGFR<\/jats:italic> mutation than control group (84.1% vs 62.0%) before PSM. The co\u2010mutation genes kirsten rat sarcoma viral oncogene homolog (<jats:italic>KRAS<\/jats:italic>) (9.4%), ataxia telangiectasia\u2010mutated (<jats:italic>ATM<\/jats:italic>) (7.4%) and mesenchymal\u2010epithelial transition (<jats:italic>MET<\/jats:italic>) (3.1%) only appeared in the control group after PSM. The BLDM\u2010LUAD harboring <jats:italic>EGFR<\/jats:italic> mutations was associated with a favorable prognosis to <jats:italic>EGFR<\/jats:italic>\u2010TKI.<\/jats:p>","DOI":"10.1002\/ijc.34878","type":"journal-article","created":{"date-parts":[[2024,2,14]],"date-time":"2024-02-14T13:03:47Z","timestamp":1707915827000},"page":"1979-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bilateral diffuse metastases in advanced lung adenocarcinoma harboring <scp>EGFR<\/scp> mutations was associated with a favorable prognosis to <scp>EGFR\u2010TKIs<\/scp>"],"prefix":"10.1002","volume":"154","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8399-4167","authenticated-orcid":false,"given":"Zhenbang","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Oncology, The Second Affiliated Hospital JiangXi Medical College, Nanchang University  Nanchang China"},{"name":"JiangXi Key Laboratory of Clinical and 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