{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:40:00Z","timestamp":1787499600331,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201001187"],"award-info":[{"award-number":["2021\u201001187"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Human papillomavirus can be contracted by sexually active women. However, only a small proportion of these infections persist and have the potential to progress into cervical cancers, indicating a significant involvement of the immune system in cervical cancer development. Despite this, our understanding of the precise contributions of genes from different immune cell types in cervical cancers remains limited. Therefore, the primary objective of our study was to investigate the potential causal relationships between specific immune cell genes and the development of cervical cancers. By accessing expression quantitative trait loci datasets of 14 distinct immune cell types and genome wide association study of cervical cancers, we employed the summary data\u2010based Mendelian randomization (SMR) along with multi\u2010single nucleotide polymorphism (SNP)\u2010based SMR to identify significant genes associated with cervical cancers. Colocalization analysis was further conducted to explore the shared genetic causality. A total of 10 genes across 11 immune cell types (26 significant gene\u2010trait associations) were found to be associated with cervical cancers after false discovery rate correction. Notably, the\n                    <jats:italic>ORMDL3<\/jats:italic>\n                    ,\n                    <jats:italic>BRK1<\/jats:italic>\n                    and\n                    <jats:italic>HMGN1<\/jats:italic>\n                    gene expression levels showed significant association with cervical cancer in specific immune cell types, respectively. These associations were supported by strong evidence of colocalization analyses. Our study has identified several genes in different immune cells that were associated with cervical cancer. However, further research is necessary to confirm these findings and provide more comprehensive insights into the association between these gene expressions and cervical cancer risk.\n                  <\/jats:p>","DOI":"10.1002\/ijc.34911","type":"journal-article","created":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T14:44:15Z","timestamp":1709736255000},"page":"149-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Revealing genes associated with cervical cancer in distinct immune cells:\n                    <scp>A<\/scp>\n                    comprehensive\n                    <scp>Mendelian<\/scp>\n                    randomization analysis"],"prefix":"10.1002","volume":"155","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics &amp; Gynecology and Pediatrics Fujian Medical University  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Department of Family Medicine and Community Health Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Functional Pathology, School of Medicine, Center for Community\u2010Based Healthcare Research and Education (CoHRE) Shimane University  Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Sundquist","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"},{"name":"Department of Family Medicine and Community Health Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Functional Pathology, School of Medicine, Center for Community\u2010Based Healthcare Research and Education (CoHRE) Shimane University  Shimane Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong  Hong Kong China"},{"name":"Department of Anesthesiology, Sanbo Brain Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5659-5045","authenticated-orcid":false,"given":"Deqiang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health Capital Medical University  Beijing China"},{"name":"Department of Clinical Sciences Malm\u00f6, Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0324-9496","authenticated-orcid":false,"given":"Jianguang","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Malm\u00f6, Center for Primary Health Care Research Lund University  Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","unstructured":"World Health Organization (WHO).2017. 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